Effect of sex steroids on pituitary responses to LH-and FSH-releasing hormone in vitro.
Effect of sex steroids on pituitary responses to LH-and FSH-releasing hormone in vitro.
复制标题
体外性类固醇对垂体对 LH 和 FSH 释放激素反应的影响。
DOI：
10.1210/endo-93-4-893
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发表时间：
1973
期刊：
影响因子：
4.8
通讯作者：
A. Arimura
中科院分区：
文献类型：
--
作者：
A. Schally;T. Redding;A. Arimura
17β-雌二醇 (E)、炔雌醇 (EE)、孕酮 (P)、5α-二氢孕酮 (5DHP)、17α-羟基孕酮 (17HP)、睾酮 (T)、二氢睾酮 (DHT) 以及 P、5DHP、17HP 与 E 的组合对 LH 和 FSH 基础释放以及对使用离体大鼠垂体在体外检查垂体对合成 LH 和 FSH 释放激素 (LH-RH/FSH-RH) 的反应。剂量为 O.OOO16-O.5 μg/ml 的 EE 抑制响应 LH-RH 的 LH 和 FSH 释放。 0.036-0.08μg/ml剂量的E增加培养基中LH的基础水平，很少增加FSH的基础水平，但抑制响应LH-RH的FSH释放。 LH-RH 诱导的 LH 释放刺激并未因较小剂量的雌激素而增强。 0.5-25μg/ml剂量的E降低LH和FSH的基础释放，并抑制对LH-RH的反应，FSH释放比LH释放更容易受到这种抑制作用的影响。剂量为 1.1-10 μg/ml 的 P 不影响 LH 和 FSH 的基础释放，剂量为 1.1-10 μg/ml 时不影响 LH 和 FSH 的基础释放。
The effects of 17β-estradiol (E), ethinylestradiol (EE), progesterone (P), 5α-dihydroprogesterone (5DHP), 17α-hydroxyprogesterone (17HP), testosterone (T), dihydrotestosterone (DHT) and combinations of P, 5DHP, 17HP with E on the basal release of LH and FSH, as well on the pituitary responses to synthetic LH and FSH-releasing hormone (LH-RH/ FSH-RH), were examined in vitro using isolated rat pituitaries. EE in doses of O.OOO16-O.5 μg/ml suppressed release of LH and FSH in response to LH-RH. E in doses of 0.036-0.08 μg/ml augmented the basal level of LH in the medium and rarely that of FSH, but inhibited the release of FSH in response to LH-RH. Stimulation of LH release induced by LH-RH was not potentiated by the smaller doses of estrogens. E in doses of 0.5-25 μg/ml lowered the basal release of LH and FSH, and inhibited the response to LH-RH, FSH release being much more susceptible to this inhibitory effect than LH release. P in doses of 1.1-10 μg/ml did not affect basal release of LH and FSH and a dose o...