Electrochemical determination of choline using nortropine-N-oxyl for a non-enzymatic system
Electrochemical determination of choline using nortropine-N-oxyl for a non-enzymatic system
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DOI：
10.1016/j.sbsr.2019.100302
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发表时间：
2020-02-01
影响因子：
5.3
通讯作者：
Sato, Katsuhiko
中科院分区：
文献类型：
--
作者：
Kashiwagi, Yoshitomo;Ono, Tetsuya;Sato, Katsuhiko
在pH7.4的磷酸盐缓冲溶液中，用循环伏安法研究了去甲托品-N-氧自由基（NNO）的电催化活性。胆碱的阳极氧化峰电流呈浓度依赖性增强，表明胆碱被NNO的电催化氧化。获得了对0.1至10 mM范围内的胆碱浓度的高线性响应。相比之下，2，2，6，6-四甲基哌啶-N-氧基（克里思）在相同条件下不能氧化胆碱。
The electrocatalytical activity of nortropine-N-oxyl (NNO) was evaluated by cyclic voltammetry in pH 7.4 phosphate buffer solution. The anodic peak current for choline was enhanced in a concentration-dependent fashion, showing that choline was oxidized by the electrocatalytic effect of NNO. A high linear response to the choline concentration ranging from 0.1 to 10 mM was obtained. In contrast, 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO) could not oxidize choline under the same conditions.