EXPERIMENTAL CAMPYLOBACTER-JEJUNI INFECTION IN HUMANS
EXPERIMENTAL CAMPYLOBACTER-JEJUNI INFECTION IN HUMANS
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DOI：
10.1093/infdis/157.3.472
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发表时间：
1988-03-01
影响因子：
6.4
通讯作者：
BLASER, MJ
中科院分区：
文献类型：
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作者：
BLACK, RE;LEVINE, MM;BLASER, MJ
由111名成年志愿者摄入的两种空肠弯曲杆菌菌株，剂量范围为8 × 10 - 10 - 10 mg/kg。102至2倍109种微生物，引起肠道疾病。感染率随剂量增加而增加，但疾病的发展并未显示出明确的剂量关系。菌株A3249导致的疾病范围从几次稀便到痢疾，平均5次稀便，粪便量为509 mL。感染菌株81-176更容易导致疾病，这些疾病更严重，平均15次排便，总粪便量为1484 mL。所有患者均有粪便白细胞。这些疾病的复杂性表明，C。空肠感染包括组织炎症。患病的志愿者产生了对C.空肠组抗原，并保护从随后的疾病，但不感染同一菌株。
Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 .times. 102 to 2 .times. 109 organisms, caused diarrheal illnesses. Rates of infection increased with dose, but development of illness did not show a clear dose relation. Resulting illnesses with strain A3249 ranged from a few loose stools to dysentery, with an average of five diarrheal stools and a volume of 509 mL. Infection with strain 81-176 was more likely to cause illness, and these illnesses were more severe, with an average of 15 stools and 1484 mL of total stool volume. All patients had fecal leukocytes. The dysenteric nature of the illnesses indicates that the pathogenesis of C. jejuni infection includes tissue inflammation. Ill volunteers developed a serum antibody response to the C. jejuni group antigen and were protected from subsequent illness but not infection with the same strain.