A possible role for TSLP in inflammatory arthritis
A possible role for TSLP in inflammatory arthritis
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DOI：
10.1016/j.bbrc.2007.03.081
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发表时间：
2007-05-25
影响因子：
3.1
通讯作者：
Nakao, Atsuhito
中科院分区：
文献类型：
--
作者：
Koyama, Kensuke;Ozawa, Tetsuro;Nakao, Atsuhito
胸腺基质淋巴细胞生成素（Thymic stromal lymphopoietin，TSLP）是一种IL-7样细胞因子，可触发树突状细胞介导的Th 2型炎症反应，被认为是变应性炎症的“主开关”。在这项研究中，我们发现TSLP和TNF-α的水平增加，如前所述，来自类风湿性关节炎（RA）患者的滑液标本与骨关节炎（OA）患者相比。此外，TNF-α上调RA和OA来源的滑膜成纤维细胞中TSLP的表达，而IFN-γ抑制TSLP的表达。此外，抗TSLP中和抗体改善了小鼠中由抗II型胶原抗体诱导的TNF-α依赖性实验性关节炎。总的来说，这些结果表明，TSLP，作为TNF-α的下游分子，可能参与炎症性关节炎的病理生理学。TSLP可能不仅在过敏性疾病中起作用，而且在炎性关节炎如RA中也起作用。(c)2007爱思唯尔公司All rights reserved.
Thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine that triggers dendritic cell-mediated Th2-type inflammatory responses and is considered as a master switch for allergic inflammation. In this study, we found increased levels of TSLP and, also TNF-alpha as previously reported, in synovial fluid specimens derived from patients with rheumatoid arthritis (RA) when compared with those from patients with osteoarthritis (OA). In addition, TNF-alpha up-regulatcd TSLP expression in RA- and OA-derived synovial fibroblasts, which was inhibited by IFN-gamma. Furthermore, anti-TSLP neutralizing antibody ameliorated a TNF-alpha-dependent experimental arthritis induced by anti-type II collagen antibody in mice. Collectively, these results suggest that TSLP, as a downstream molecule of TNF-alpha, may be involved in the pathophysiology of inflammatory arthritis. TSLP might thus play a role not only in allergic diseases but also in inflammatory arthritis such as RA. (c) 2007 Elsevier Inc. All rights reserved.