Eliminating metabolic abnormalities of portacaval shunting by restoring normal liver blood flow.
Eliminating metabolic abnormalities of portacaval shunting by restoring normal liver blood flow.
复制标题
通过恢复正常的肝血流消除门静脉分流的代谢异常。
DOI：
10.1152/ajpendo.1996.270.6.e1037
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Hawkins,RA
中科院分区：
文献类型：
--
作者：
Hawkins,PA;DeJoseph,MR;Hawkins,RA
门腔静脉分流术引起多种解剖、代谢和生理变化。然而，还没有确定这些变化是否以及在多大程度上是永久性的，经过一段时间的分流。我们准备了三组大鼠用于研究恢复过程。一组行侧侧分流术3周，一组行侧侧分流术2周，然后恢复正常肝循环1周，一组（对照组）行假手术。侧侧分流导致肝萎缩、血浆氨增加、血浆和脑氨基酸谱改变、血浆葡萄糖降低和中性氨基酸穿过血脑屏障的转运增加。通过分流修复术恢复正常的肝循环模式后，肝脏在1天内恢复正常大小。除血糖仍比对照值低约15%外，与肝功能障碍相关的所有异常均消失。
Portacaval shunting causes a variety of anatomic, metabolic, and physiological changes. However, it has not been determined whether, and to what degree, these changes are permanent after a sustained period of shunting. We prepared three groups of rats for study of the recovery process. One group had side-to-side shunts for 3 wk, one group had side-to-side shunts for 2 wk followed by the restoration of normal liver circulation for 1 wk, and one group (control) had sham operations. Side-to-side shunting causes liver atrophy, increased plasma ammonia, altered plasma and brain amino acid spectra, decreased plasma glucose, and increased transport of neutral amino acids across the blood-brain barrier. After restoration of the normal pattern of liver circulation by shunt repair, the liver regained its normal size within 1 day. All abnormalities associated with liver dysfunction disappeared with the exception of plasma glucose, which remained approximately 15% lower than control values.