An Update on the Multifaceted Role of NF-kappaB in Endometriosis.
An Update on the Multifaceted Role of NF-kappaB in Endometriosis.
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核因子κB在子宫内膜异位症中多方面作用的最新进展
DOI：
10.7150/ijbs.72707
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发表时间：
2022
影响因子：
9.2
通讯作者：
Zhang, Xinmei
中科院分区：
文献类型：
--
作者：
Liu, Yuanmeng;Wang, Jianzhang;Zhang, Xinmei
子宫内膜异位症是育龄妇女常见的妇科疾病，发病机制不明，治疗方法有限。大量证据表明，NF-κB信号传导，炎症反应的主要调节因子，在子宫内膜异位症病变中过度活跃，并有助于子宫内膜异位症的发生、进展和复发。雌激素、孕激素、氧化应激和非编码RNA等多种因素可调节子宫内膜异位症中NF-κB信号通路。在本综述中，我们讨论了这些因素在子宫内膜异位症进展过程中调节NF-κB的机制，并提供了NF-κB在影响子宫内膜异位症细胞、腹腔巨噬细胞（PMs）以及子宫内膜异位症相关症状（如疼痛和不孕）中的作用的最新进展。此外，本文还对NF-κB信号通路的阻断药物进行了综述，包括植物源性药物、NF-κB抑制剂、其他已知药物以及通过药物-基因相互作用数据库预测的潜在抗NF-κB药物。本文就NF-κB B信号通路在子宫内膜异位症中的多方面作用进行综述，并对NF-κ B靶向治疗进行详细总结。
Endometriosis remains a common but challenging gynecological disease among reproductive-aged women with an unclear pathogenesis and limited therapeutic options. Numerous pieces of evidence suggest that NF-κB signaling, a major regulator of inflammatory responses, is overactive in endometriotic lesions and contributes to the onset, progression, and recurrence of endometriosis. Several factors, such as estrogen, progesterone, oxidative stress, and noncoding RNAs, can regulate NF-κB signaling in endometriosis. In the present review, we discuss the mechanisms by which these factors regulate NF-κB during endometriosis progression and provide an update on the role of NF-κB in affecting endometriotic cells, peritoneal macrophages (PMs) as well as endometriosis-related symptoms, such as pain and infertility. Furthermore, the preclinical drugs for blocking NF-κB signaling in endometriosis are summarized, including plant-derived medicines, NF-κB inhibitors, other known drugs, and the potential anti-NF-κB drugs predicted through the Drug-Gene Interaction Database. The present review discusses most of the studies concerning the multifaceted role of NF-κB signaling in endometriosis and provides a summary of NF-κB-targeted treatment in detail.
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