Axon regeneration mechanisms: insights from C. elegans.
Axon regeneration mechanisms: insights from C. elegans.
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DOI：
10.1016/j.tcb.2011.08.003
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发表时间：
2011-10
影响因子：
19
通讯作者：
Chisholm AD
中科院分区：
文献类型：
--
作者：
Chen L;Chisholm AD
Understanding the mechanisms of axon regeneration is of great importance to develop therapeutic treatments for spinal cord injury or stroke. Axon regeneration has long been studied in various vertebrate and invertebrate models, but until recently had not been analyzed in the genetically tractable model organism Caenorhabditis elegans. The small size, simple neuroanatomy, and transparency of C. elegans allows single fluorescently labeled axons to be severed in live animals using laser microsurgery. Many neurons in C. elegans are capable of regenerative regrowth, and can in some cases re-establish functional connections. Large-scale genetic screens have begun to elucidate the genetic basis of axon regrowth.
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通讯作者：
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DOI：
10.1083/jcb.200607098
发表时间：
2007-02-12
期刊：
The Journal of cell biology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1126/science.1165527
发表时间：
2009-02-06
期刊：
Science (New York, N.Y.)
影响因子：
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