Comparison of eardrum mobility in acute otitis media and otitis media with effusion models.
Comparison of eardrum mobility in acute otitis media and otitis media with effusion models.
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DOI：
10.1097/mao.0b013e3182941a95
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Gan RZ
中科院分区：
文献类型：
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作者：
Guan X;Li W;Gan RZ
探讨急性中耳炎（AOM）与实验性分泌性中耳炎（OME）鼓膜活动度的差异。本研究纳入了33只Hartley豚鼠。分别通过经眼球向中耳内注射肺炎链球菌和脂多糖建立AOM和OME。接种后3天，用耳镜和组织切片评估中耳的形态学变化。用激光多普勒测振仪测量了鼓膜（TM）对纯音的振动响应。AOM耳可见化脓性积液、听骨粘连、鼓膜及中耳粘膜增厚; OME耳可见浆液性积液、鼓膜及中耳粘膜增厚较少。AOM耳TM位移低于OME耳，尤其在0.2 ~ 4kHz时。AOM和OME耳TM活动度的差异主要是由于AOM细菌感染时中耳听骨结构的改变所致。
To investigate the eardrum mobility difference between acute otitis media (AOM) and experimental otitis media with effusion (OME). Thirty-three Hartley guinea pigs were included in this study. The AOM and OME were created by transbullar injection of Streptococcus pneumoniae and lipopolysaccharide into the middle ear, respectively. Three days post inoculation, the morphological changes of the middle ear were assessed with otoscopy and histological sections. Vibrations of the tympanic membrane (TM) at umbo in response to pure tone sound were measured using laser Doppler vibrometry. The purulent effusion, ossicular adhesion, and thickened TM and middle ear mucosa were observed in the AOM ears, and the OME ears had serous effusion and less thickened TM and mucosa in the middle ear. The displacement of TM in AOM was lower than that in OME ears, especially at 0.2–4 kHz. The TM mobility difference between the AOM and OME ears were mainly caused by the middle ear ossicular structure changes during the bacterial infection in AOM.