BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.
BDNF Responses in Healthy Older Persons to 35 Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with Working Memory Function.
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DOI：
10.3233/jad-160593
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Mohammed AK
中科院分区：
文献类型：
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作者：
Håkansson K;Ledreux A;Daffner K;Terjestam Y;Bergman P;Carlsson R;Kivipelto M;Winblad B;Granholm AC;Mohammed AK
脑源性神经营养因子（BDNF）通过介导响应于身体活动和环境丰富的皮质厚度和突触密度的变化在脑可塑性中起核心作用。以前的研究表明，体育锻炼可以增加血清和大脑中的BDNF水平，但没有其他研究研究探讨了不同类型的活动与体育锻炼在影响BDNF水平方面的能力。通过使用平衡交叉实验设计，我们将19名健康的老年人暴露在35分钟的体育锻炼，认知训练和正念练习中，并比较了三种活动之间成熟BDNF水平的变化。我们发现，在同一个人身上，一次体育锻炼对血清BDNF水平的影响比认知训练或正念练习要大得多。这是第一项关于老年健康人身体活动对BDNF的直接影响的研究，也是第一项证明血清BDNF对急性体育锻炼和工作记忆功能之间存在关联的研究。我们的结论是，我们发现的BDNF增加后，体育锻炼更可能有一个周边比中央起源，但干预后的BDNF水平和认知功能之间的关联可能有影响血清中的BDNF反应性作为一个潜在的标志认知健康。
Brain-derived neurotrophic factor (BDNF) has a central role in brain plasticity by mediating changes in cortical thickness and synaptic density in response to physical activity and environmental enrichment. Previous studies suggest that physical exercise can augment BDNF levels, both in serum and the brain, but no other study has examined how different types of activities compare with physical exercise in their ability to affect BDNF levels. By using a balanced cross over experimental design, we exposed nineteen healthy older adults to 35-minute sessions of physical exercise, cognitive training, and mindfulness practice, and compared the resulting changes in mature BDNF levels between the three activities. We show that a single bout of physical exercise has significantly larger impact on serum BDNF levels than either cognitive training or mindfulness practice in the same persons. This is the first study on immediate BDNF effects of physical activity in older healthy humans and also the first study to demonstrate an association between serum BDNF responsivity to acute physical exercise and working memory function. We conclude that the BDNF increase we found after physical exercise more probably has a peripheral than a central origin, but that the association between post-intervention BDNF levels and cognitive function could have implications for BDNF responsivity in serum as a potential marker of cognitive health.