Effects of eye position upon activity of neurons in macaque superior colliculus
Effects of eye position upon activity of neurons in macaque superior colliculus
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DOI：
10.1152/jn.00639.2005
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发表时间：
2006-01-01
影响因子：
2.5
通讯作者：
Segraves, MA
中科院分区：
文献类型：
--
作者：
Campos, M;Cherian, A;Segraves, MA
眼睛位置对猕猴上丘神经元活动的影响。 《神经生理学杂志》95：505-526，2006 年。首次发表于 2005 年 9 月 28 日； doi：10.1152/jn。 00639.2005。我们检查了清醒行为恒河猴在执行标准动眼神经任务期间以及在观看自然图像时进行自我引导眼球运动期间上丘深层神经元的活动。标准任务用于根据既定标准来表征神经元的活动。自然观察范式能够对分布在广泛眼睛位置的扫视和注视期间的神经元活动进行采样。眼球运动行为的两个不同方面有助于调节这些神经元的放电活动。眼跳幅度和方向的公认影响在眼跳开始时最强且最普遍。然而，这些神经元的活动也受到眼睛眼眶位置的影响，这种效应在注视间隔期间观察得最好。许多神经元对这两个参数都很敏感，并且它们的扫视矢量和眼睛位置响应场的方向往往是对齐的。神经元样本包括单独或组合的视觉、累积和爆发活动。所有这些活动类型都包含在具有显着眼位置调节的神经元亚群中，尽管位置调节在具有累积或爆发活动的神经元中更常见，而在具有视觉活动的神经元中不太常见。上丘中眼睛位置和扫视矢量信号的存在可能对于其在眼睛和头部的组合运动的规划和引导中的作用很重要。
Effects of eye position upon activity of neurons in macaque superior colliculus. J Neurophysiol 95: 505-526, 2006. First published September 28, 2005; doi:10.1152/jn. 00639.2005. We examined the activity of neurons in the deep layers of the superior colliculus of awake behaving rhesus monkeys during the performance of standard oculomotor tasks as well as during self-guided eye movements made while viewing natural images. The standard tasks were used to characterize the activity of neurons based on established criteria. The natural viewing paradigm enabled the sampling of neuronal activity during saccades and fixations distributed over a wide range of eye positions. Two distinct aspects of eye-movement behavior contributed to the modulation of firing activity in these neurons. The well-established influence of saccade amplitude and direction was strongest and most prevalent surrounding the time of the start of the saccade. However, the activity of these neurons was also affected by the orbital position of the eyes, and this effect was best observed during intervals of fixation. Many neurons were sensitive to both parameters, and the directions of their saccade vector and eye position response fields tended to be aligned. The sample of neurons included visual, build-up, and burst activities, alone or in combination. All of these activity types were included in the subpopulation of neurons with significant eye-position tuning, although position tuning was more common in neurons with build-up or burst activity and less common in neurons with visual activity. The presence of both eye-position as well as saccade-vector signals in the superior colliculus is likely important for its role in the planning and guidance of combined movements of the eyes and head.