Genomic Disparities in Breast Cancer Among Latinas.
Genomic Disparities in Breast Cancer Among Latinas.
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DOI：
10.1177/107327481602300407
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Vadaparampil ST
中科院分区：
文献类型：
--
作者：
Lynce F;Graves KD;Jandorf L;Ricker C;Castro E;Moreno L;Augusto B;Fejerman L;Vadaparampil ST
乳腺癌是美国拉丁美洲人中最常见的癌症，也是该人群中癌症相关死亡的主要原因。拉丁裔倾向于在较晚的阶段被诊断，并且比非西班牙裔白色人具有更差的预后特征。遗传和基因组因素可能有助于观察到的拉丁美洲乳腺癌的健康差异。我们提供了我们目前的理解和需要在癌症预防和控制连续体中填补的现有差距的景观。我们总结了有关乳腺癌遗传风险的高和中度突变基因突变的现有数据，以及拉丁裔人群对遗传咨询和检测的认识和吸收差异的相关文献。我们还讨论了拉丁美洲人常见的遗传多态性和乳腺癌的风险。在治疗方面，我们研究了拉丁裔乳腺癌患者的肿瘤基因组学和药物基因组学。随着美国人口的不断多样化，将遗传和基因组研究扩展到这一服务不足和研究不足的人群至关重要。通过了解不同种族人群中乳腺癌的风险，我们将更好地为癌症的早期阶段提供治疗进展，确定更有效和理想的毒性更小的治疗方案，并提高生存率。
Breast cancer is the most common cancer diagnosed among Latinas in the United States and the leading cause of cancer-related death among this population. Latinas tend to be diagnosed at a later stage and have worse prognostic features than their non-Hispanic white counterparts. Genetic and genomic factors may contribute to observed breast cancer health disparities in Latinas. We provide a landscape of our current understanding and the existing gaps that need to be filled across the cancer prevention and control continuum. We summarize available data on mutations in high and moderate penetrance genes for inherited risk of breast cancer and the associated literature on disparities in awareness of and uptake of genetic counseling and testing in Latina populations. We also discuss common genetic polymorphisms and risk of breast cancer in Latinas. In the treatment setting, we examine tumor genomics and pharmacogenomics in Latina patients with breast cancer. As the US population continues to diversify, extending genetic and genomic research into this underserved and understudied population is critical. By understanding the risk of breast cancer among ethnically diverse populations, we will be better positioned to make treatment advancements for earlier stages of cancer, identify more effective and ideally less toxic treatment regimens, and increase rates of survival.
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影响因子：
3.5
作者：
Abugattas, J.;Llacuachaqui, M.;Narod, S. A.
通讯作者：
Narod, S. A.
影响因子：
3.8
作者：
Boone, Stephanie D.;Baumgartner, Kathy B.;Baumgartner, Richard N.;Connor, Avonne E.;Pinkston, Christina M.;John, Esther M.;Hines, Lisa M.;Stern, Mariana C.;Giuliano, Anna R.;Torres-Mejia, Gabriela;Brock, Guy N.;Groves, Frank D.;Kerber, Richard A.;Wolff, Roger K.;Slattery, Martha L.
通讯作者：
Slattery, Martha L.
DOI：
10.1111/tbj.12545
发表时间：
2016-03
期刊：
The breast journal
影响因子：
--
作者：
Bonner D;Cragun D;Reynolds M;Vadaparampil ST;Pal T
通讯作者：
Pal T
影响因子：
3.8
作者：
Bargallo-Rocha, Juan Enrique;Lara-Medina, Fernando;Valentine, William J.
通讯作者：
Valentine, William J.
影响因子：
3.8
作者：
Allman R;Dite GS;Hopper JL;Gordon O;Starlard-Davenport A;Chlebowski R;Kooperberg C
通讯作者：
Kooperberg C