A SURFACE-FILM STUDY OF THE LATERAL PACKING OF PHOSPHATIDYL-CHOLINE AND CHOLESTEROL
A SURFACE-FILM STUDY OF THE LATERAL PACKING OF PHOSPHATIDYL-CHOLINE AND CHOLESTEROL
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DOI：
10.1016/0009-3084(82)90016-0
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
LUNDBERG, B
中科院分区：
文献类型：
--
作者：
LUNDBERG, B
用平衡铺展压和表面平衡法研究了磷脂酰胆碱（PC）和胆固醇（CHL）之间的相互作用。卵磷脂（EPC），二棕榈酰磷脂酰胆碱（DPPC）和CHL组成的混合膜的研究强烈表明，所有3个组件是可混溶的膜和CHL与PC随机相互作用。从其中2个PC脂肪酸链被1个CHL取代的六边形链堆积开始，在CHL摩尔分数为0.20、0.33、0.50和1.00时出现临界比例。
The interaction between phosphatidylcholine (PC) and cholesterol (CHL) was studied with equilibrium spreading pressure, and surface balance measurements. Studies of mixed films composed of egg phosphatidylcholine (EPC), dipalmitoylphosphatidylcholine (DPPC) and CHL strongly indicate that all 3 components are miscible in the films and that CHL interacts randomly with the PCs. Starting from a hexagonal chain packing where 2 PC fatty acid chains are replaced by 1 CHL critical proportions arise at CHL mole fractions of 0.20, 0.33, 0.50 and 1.00.