Association between benzodiazepines and suicide risk: a matched case-control study
Association between benzodiazepines and suicide risk: a matched case-control study
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DOI：
10.1186/s12888-019-2312-3
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发表时间：
2019-10-26
期刊：
影响因子：
4.4
通讯作者：
Sellin, Tabita
中科院分区：
文献类型：
--
作者：
Cato, Ville;Hollandare, Fredrik;Sellin, Tabita
背景目前尚不清楚苯二氮卓类药物是否会增加自杀风险。这项研究的目的是通过比较自杀的精神病患者和一组匹配的对照组之间的精神药理学干预，来检验苯二氮类药物与自杀风险增加相关的假设。方法病例组为瑞典奥雷布洛县自杀精神病患者154例，男101例，女53例；年龄13~96岁。每个病例选择年龄、性别和主要精神病学诊断相匹配的对照精神病患者。采用二元Logistic回归方法计算调整前后模型的优势比。结果苯二氮类药物处方在病例组较对照组多见(65/154[42.2%]对43/154[27.9%]，P=0.009，优势比：1.89[95%可信区间：1.17~3.03])。在调整了以前的自杀未遂和躯体住院的模型中，这种关联仍然显著(优势比：1.83[95%CI：1.06-3.14])。在使用任何其他类型的精神药物方面，两组之间没有统计学上的显著差异。结论苯二氮卓类药物的使用可能增加自杀风险。然而，这项研究受到潜在的适应症偏差的限制。
Background It is unclear whether benzodiazepines increase the risk of suicide. The aim of this study was to test the hypothesis that benzodiazepines are associated with an increased risk of suicide, by comparing psychopharmacological interventions between psychiatric patients who committed suicide and a group of matched controls. Methods The case group comprised 154 psychiatric patients (101 men, 53 women; age range: 13-96 years) who had committed suicide in orebro County, Sweden. Control psychiatric patients matched by age, sex, and main psychiatric diagnosis were selected for each case. Binary logistic regression was used to calculate odds ratios in unadjusted and adjusted models. Results Benzodiazepine prescriptions were more common among cases than controls (65/154 [42.2%] versus 43/154 [27.9%], p = 0.009, odds ratio: 1.89 [95% CI: 1.17-3.03]). This association remained significant in a model adjusted for previous suicide attempts and somatic hospitalizations (odds ratio: 1.83 [95% CI: 1.06-3.14]). No statistically significant differences were seen between the groups in the use of any other subtype of psychopharmaceutical agent. Conclusions These data indicate that benzodiazepine use may increase the risk of suicide. However, this study is limited by the potential for indication bias.