Effect of high doses of aspirin on pulmonary hemodynamics and lung water.
Effect of high doses of aspirin on pulmonary hemodynamics and lung water.
复制标题
高剂量阿司匹林对肺血流动力学和肺水的影响。
DOI：
10.1152/ajpheart.1985.248.2.h225
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Maron,MB
中科院分区：
文献类型：
--
作者：
Maron,MB
本研究的目的是确定是否阿司匹林，在剂量升高血浆水杨酸盐浓度的水杨酸盐诱导的肺水肿患者中报告的值，产生肺血管收缩犬，离体灌注左下肺叶（LLL）的准备。在10例LLL中，阿司匹林（平均97.8 mg/dl血浆）导致LLL动脉压从9.1 +/- 0.3 Torr升高至23.0 +/- 1.8（SE）Torr。相比之下，在安慰剂治疗的对照LLL中未观察到血管压力变化。结构不同的环氧化酶抑制剂甲氨蝶呤钠和吲哚美辛对阿司匹林的反应相似，表明前列腺素环氧化酶产物参与血管收缩的机制。双闭塞技术用于定位血管收缩的部位。结果表明，所有三种药物引起肺叶动脉和静脉张力增加。虽然高剂量阿司匹林在离体灌注的LLL中产生肺血管收缩，但阿司匹林治疗的LLL比对照叶获得更少的重量和血管外水。
The purpose of this study was to determine if aspirin, in doses that elevate plasma salicylate concentrations to values reported in patients with salicylate-induced pulmonary edema, produce pulmonary vasoconstriction in a canine, isolated perfused left lower lung lobe (LLL) preparation. In 10 LLL's, aspirin (avg 97.8 mg/dl plasma) caused LLL arterial pressure to rise from 9.1 +/- 0.3 to 23.0 +/- 1.8 (SE) Torr. In contrast, no vascular pressure changes were observed in placebo-treated control LLL's. Sodium meclofenamate and indomethacin, structurally dissimilar cyclooxygenase inhibitors, elicited similar responses to aspirin, suggesting that a mechanism involving products of prostaglandin cyclooxygenase was involved in producing the vasoconstriction. The double-occlusion technique was used to localize the sites of the vasoconstriction. The results suggested that all three drugs caused both lobar arterial and venous tone to increase. Although high doses of aspirin produced pulmonary vasoconstriction in the isolated, perfused LLL, the aspirin-treated LLL's gained less weight and extravascular water than the control lobes.