Horizontal Gene Transfer and the History of Life
Horizontal Gene Transfer and the History of Life
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DOI：
10.1101/cshperspect.a018036
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发表时间：
2016-04-01
影响因子：
7.2
通讯作者：
Szoellosi, Gergely J.
中科院分区：
文献类型：
--
作者：
Daubin, Vincent;Szoellosi, Gergely J.
微生物获得DNA的来源多种多样。在过去的几十年里，基因组测序的发展表明，水平基因转移是一种主要的进化力量，在整个进化过程中不断重塑基因组。然而，由于生命的历史最终必须从基因系统发育中推断出来，缺乏解释水平基因转移的方法已经使生命之树的概念陷入混乱。因此，许多问题仍未解决，但新兴的方法发展有望利用水平基因转移所传达的信息，而这些信息目前仍未得到利用。
Microbes acquire DNA from a variety of sources. The last decades, which have seen the development of genome sequencing, have revealed that horizontal gene transfer has been a major evolutionary force that has constantly reshaped genomes throughout evolution. However, because the history of life must ultimately be deduced from gene phylogenies, the lack of methods to account for horizontal gene transfer has thrown into confusion the very concept of the tree of life. As a result, many questions remain open, but emerging methodological developments promise to use information conveyed by horizontal gene transfer that remains unexploited today.