Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease.
Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease.
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DOI：
10.3233/jad-230061
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发表时间：
2023-05
期刊：
影响因子：
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通讯作者：
J. Blusztajn;B. Slack
中科院分区：
文献类型：
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作者：
J. Blusztajn;B. Slack
许多研究表明，在阿尔茨海默病（AD）的多种代谢途径的缺陷，在尸检大脑和脑脊液中检测到体内。然而，直到能够测量单个样品中数千种代谢物的技术出现之前，还不可能对这些异常的相对大小进行排名。最近的一项研究提供了证据表明，脑中最丰富的磷脂：磷脂酰胆碱和磷脂酰乙醇胺的异常周转构成了AD的主要代谢病理学。我们将这一观察的历史背景下，并讨论了磷脂代谢在AD发病机制的核心作用的影响。
Numerous studies have demonstrated defects in multiple metabolic pathways in Alzheimer's disease (AD), detected in autopsy brains and in the cerebrospinal fluid in vivo. However, until the advent of techniques capable of measuring thousands of metabolites in a single sample, it has not been possible to rank the relative magnitude of these abnormalities. A recent study provides evidence that the abnormal turnover of the brain's most abundant phospholipids: phosphatidylcholine and phosphatidylethanolamine, constitutes a major metabolic pathology in AD. We place this observation in a historical context and discuss the implications of a central role for phospholipid metabolism in AD pathogenesis.