Kindling‐Related Changes in Afterdischarge “Thresholds”
Kindling‐Related Changes in Afterdischarge “Thresholds”
复制标题
与点燃相关的后放电“阈值”变化
DOI：
10.1111/j.1528-1157.1976.tb03397.x
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发表时间：
1976
期刊：
影响因子：
5.6
通讯作者：
D. Scheffner
中科院分区：
文献类型：
--
作者：
J. Pinel;R. Skelton;R. Mucha;A. Portera;D. Scheffner
每 60 秒一次以逐渐增加的电流强度对大鼠施加杏仁核刺激，直到通过刺激电极记录后放电 (AD)。这些初始 AD“阈值”(x = 75 μA) 在 4 天的时间内通过一系列 12 次阈值下刺激而降低。相比之下，以相同方案但更高强度（400 μA）进行的刺激提高了 AD 阈值。 AD 阈值的降低是相对永久性的，而升高的阈值随后通过一系列阈下刺激或 7 天无刺激期降低至控制水平。实验1完成两天后，所有大鼠均注射低剂量的戊四氮。实验动物中戊四氮引起的癫痫症状的发生率比之前仅接受阈值估计程序的对照受试者要高得多。
Amygdaloid stimulations were applied to rats at gradually increasing current intensities once every 60 sec until an afterdischarge (AD) was recorded through the stimulation electrode. These initial AD “thresholds” (x = 75 μA) were reduced over a 4‐day period by a series of 12 subthreshold stimulations. In contrast, stimulations administered on the same regimen but at a higher intensity (400 μA) had raised the AD threshold. The decreases in the AD threshold were relatively permanent, whereas the elevated thresholds were subsequently reduced to control levels by a series of subthreshold stimulations or by a 7‐day stimulation‐free period. Two days following the completion of Experiment 1, all of the rats were injected with a low dose of pentylenetetrazol. The incidence of pentylenetetrazol‐induced epileptic symptoms was much higher in the experimental animals than in the control subjects previously subjected only to the threshold estimation procedure.