Strong association between shiga toxin-producing Escherichia coli O157 and virulence genes stx2 and eae as possible explanation for predominance of serogroup O157 in patients with haemolytic uraemic syndrome
Strong association between shiga toxin-producing Escherichia coli O157 and virulence genes stx2 and eae as possible explanation for predominance of serogroup O157 in patients with haemolytic uraemic syndrome
复制标题
DOI：
10.1007/s10096-003-1025-0
复制
发表时间：
2003-12-01
影响因子：
4.5
通讯作者：
Tsch채pe, H
中科院分区：
文献类型：
--
作者：
Werber, D;Fruth, A;Tsch채pe, H
本研究的目的是探讨产滋贺毒素大肠杆菌（STEC）O 157与胃肠炎患者STEC中同时存在stx（2）和eae毒力基因之间的关系。在德国，溶血性尿毒综合征（HUS）患者STEC分离株中血清群O 157的比例显著高于胃肠炎患者STEC分离株。原因不明。stx（2）和eae毒力基因与严重疾病相关，与血清型无关。2000-2001年从德国范围内基于实验室的监测系统收集的患者STEC相关胃肠炎数据
The aim of this study was to investigate the association between Shiga toxin-producing Escherichia coli (STEC) O157 and the simultaneous presence of the virulence genes stx(2) and eae in STEC from patients with gastroenteritis. In Germany, the proportion of serogroup O157 is substantially higher among STEC isolates from patients with haemolytic uraemic syndrome (HUS) than among STEC isolates from patients with gastroenteritis. The reason for this is unknown. Independent of serogroup, the virulence genes stx(2) and eae have been associated with severe disease. Data collected in 2000-2001 from a Germany-wide laboratory-based surveillance system for STEC-associated gastroenteritis in patients