Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development
Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development
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DOI：
10.1016/j.mcn.2005.09.010
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发表时间：
2006-02-01
影响因子：
3.5
通讯作者：
deLapeyrière, O
中科院分区：
文献类型：
--
作者：
Dessaud, E;Salaün, D;deLapeyrière, O
我们分离到一个新的基因，从基因组织到预测的3D结构，它具有Ly-6/神经毒素超家族的所有特征。由于它在神经系统中优先表达，我们将其命名为lynx2，类似于nAChR调节剂lynx1。在胚胎和出生后的小鼠中，Lynx2在有丝分裂后的中枢和外周神经元中表达。这些包括运动神经元、感觉神经元、中间神经元和自主神经系统神经元的亚群。此外，Lynx2在肢芽中生长的神经周围瞬时表达。将其与该家族的另外两个成员lynx1和ly-6h的时空表达模式进行比较，表明这些基因在不同的和重叠的神经元群体中都能检测到。(C)2005 Elsevier Inc.保留所有权利。
We isolated a new gene which shares all the features of the Ly-6/ neurotoxin superfamily, from gene organization to predicted 3D structure. As it is preferentially expressed in the nervous system, we called this gene lynx2, by analogy with lynx1, a nAChR modulator. In embryonic and postnatal mouse, lynx2 is expressed in postmitotic central and peripheral neurons. These include subpopulations of motor neurons, sensory neurons, interneurons and neurons of the autonomous nervous system. In addition, lynx2 is transiently expressed around the growing nerves in the limb bud. Comparison of its spatio-temporal expression pattern with that of two other members of this family, lynx1 and ly-6h, shows that these genes are detected both in distinct and overlapping neuron populations. (c) 2005 Elsevier Inc. All rights reserved.