EFFECTS OF CAPSAICIN ON MICTURITION AND ASSOCIATED REFLEXES IN RATS
EFFECTS OF CAPSAICIN ON MICTURITION AND ASSOCIATED REFLEXES IN RATS
复制标题
DOI：
10.1152/ajpregu.1993.265.1.r132
复制
发表时间：
1993-07-01
影响因子：
--
通讯作者：
DEGROAT, WC
中科院分区：
文献类型：
--
作者：
CHENG, CL;MA, CP;DEGROAT, WC
本文研究了辣椒素对乌拉坦麻醉雌性大鼠排尿和相关反射的影响。实验前4d皮下注射辣椒素或溶媒溶液125 mg/kg，实验期间皮下注射辣椒素或溶媒溶液50~100 mg/kg。当膀胱缓慢充盈(0.052毫升/分钟)或当膀胱膨胀超过排尿阈值并保持恒定容量时，通过导尿管测量膀胱内压力来记录膀胱的活动。辣椒素对膀胱功能的各项参数，包括排尿量阈值、反射性膀胱收缩的幅度、持续时间和间期均无明显影响。然而，辣椒素处理显著减少(减少80%)伴随反射性膀胱收缩的动脉升压反应，并且减少大约一半的动物的膀胱活动被子宫颈刺激所抑制。大剂量辣椒素(50 mg/kg sc)引起膀胱活动的急性阻断，持续8-15小时，这种作用是由于对排尿反射通路的有髓传入或传出成分的作用。结论：辣椒素敏感传入神经对大鼠排尿功能不是必需的。然而，这些传入参与了调节膀胱活动的颈膀胱反射机制，以及由等长膀胱收缩引发的血管反射。
The effect of capsaicin on micturition and associated reflexes was studied in urethan-anesthetized female rats. Capsaicin or vehicle solution were administered 4 days before the experiment in a dose of 125 mg/kg sc or during the experiment in a dose of 50-100 mg/kg sc. Activity of the urinary bladder was recorded by measuring intravesical pressure via a urethral catheter while slowly filling (0.052 ml/min) the bladder or when the bladder was distended beyond the micturition threshold and maintained at a constant volume. Pretreatment with capsaicin did not significantly change various parameters of urinary bladder function including micturition volume threshold or the amplitude, duration, and interval between reflex bladder contractions. However, capsaicin pretreatment significantly reduced (80% decrease) the arterial pressor responses accompanying reflex bladder contractions and reduced by approximately one-half the percentage of animals in which bladder activity was inhibited by stimulation of the uterine cervix. A large dose of capsaicin (50 mg/kg sc) elicited an acute block of bladder activity that persisted for 8-15 h. This effect is attributable to an action on myelinated afferent or efferent components of the micturition reflex pathway. It is concluded that capsaicin-sensitive afferents are not essential for the performance of micturition in the rat. However, these afferents are involved in cervicovesical reflex mechanisms that modulate bladder activity and in vascular reflexes triggered by isometric bladder contractions.