Protein phosphatases take the mitotic stage
Protein phosphatases take the mitotic stage
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DOI：
10.1016/j.ceb.2009.08.003
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发表时间：
2009-12-01
影响因子：
7.5
通讯作者：
Visintin, Rosella
中科院分区：
文献类型：
--
作者：
De Wulf, Peter;Montani, Francesca;Visintin, Rosella
在20世纪80年代鉴定出细胞周期蛋白依赖性激酶之后，激酶被誉为有丝分裂的指导者。虽然激酶的作用必然是可逆的，但直到最近才认识到特异性磷酸酶参与有丝分裂。现在的研究揭示了有丝分裂事件的及时执行如何依赖于激酶和磷酸酶之间微妙的相互作用。迄今为止，特征最好的有丝分裂磷酸酶是进入有丝分裂所需的Cdc 25和控制芽殖酵母有丝分裂退出的Cdc 14。最近的工作已经暴露了保守的丝氨酸-苏氨酸磷酸酶PP 1和PP 2A作为各种有丝分裂过程的关键调节剂。
Following the identification of cyclin-dependent kinases in the 1980s, kinases were hailed as the directors of mitosis. Although the action of kinases must necessarily be reversible, only recently has the involvement of specific phosphatases in mitosis become appreciated. Studies are now revealing how the timely execution of mitotic events depends on the delicate interplay between kinases and phosphatases. To date, the best-characterized mitotic phosphatases are Cdc25, that is required for entry into mitosis and Cdc14, that controls exit from mitosis in budding yeast. Recent work has now exposed the conserved serine-threonine phosphatases PP1 and PP2A as key regulators of various mitotic processes.