Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia

Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia
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DOI:
10.1046/j.1523-1755.2000.07512.x
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发表时间:
2000-04-01
影响因子:
19.6
通讯作者:
Norman, JT
Norman, JT
中科院分区:
医学1区
文献类型:
--
作者:
Fine, LG;Bandyopadhyay, D;Norman, JT

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慢性肾病为何进展的问题只是最近才被研究的话题。蛋白尿等推定原因并不能解释进行性肾病的所有方面。提出了另一种机制,即慢性缺氧,可能可以更好地解释进行性肾病的某些要素,但该假设的要素仍有待进一步研究。
The question of why chronic renal diseases progress is a topic only recently investigated. Putative causes such as proteinuria do not account for all aspects of progressive renal disease. An alternative mechanism, chronic hypoxia, is proposed that might better explain certain elements of progressive renal disease, but elements of the hypothesis remain subject to further study.