Intrinsic functional relations between human cerebral cortex and thalamus
Intrinsic functional relations between human cerebral cortex and thalamus
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DOI：
10.1152/jn.90463.2008
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发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Raichle, Marcus E.
中科院分区：
文献类型：
--
作者：
Zhang, Dongyang;Snyder, Abraham Z.;Raichle, Marcus E.
即使没有明确的刺激或明显的反应，大脑也是活跃的。当用静息态功能磁共振成像（fMRI）血氧水平依赖（BOLD）成像评估时，这种活动与大脑皮层的特定网络高度相关。丘脑在这种内在活动中的作用是未知的，尽管它在大脑皮层的功能中起着关键作用。在这里，我们绘制了人类丘脑和大脑皮层之间的休息状态活动的相关性，在成年人使用功能磁共振成像BOLD成像。基于这种内在脑活动的功能测量，我们将丘脑划分为核群，这些核群与从非人灵长类动物推断的死后人类组织学和连接解剖学相对应。这种结构/功能的对应关系在静息状态下的活动是最强的每个大脑半球和同侧丘脑。然而，每个半球也与对侧丘脑密切相关，这种模式不能归因于已知的丘脑皮质单突触连接。这些结果扩展了我们对人类大脑的固有网络组织的理解到丘脑，并突出了静息状态fMRI BOLD成像阐明丘脑皮质关系的潜力。
The brain is active even in the absence of explicit stimuli or overt responses. This activity is highly correlated within specific networks of the cerebral cortex when assessed with resting-state functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) imaging. The role of the thalamus in this intrinsic activity is unknown despite its critical role in the function of the cerebral cortex. Here we mapped correlations in resting-state activity between the human thalamus and the cerebral cortex in adult humans using fMRI BOLD imaging. Based on this functional measure of intrinsic brain activity we partitioned the thalamus into nuclear groups that correspond well with postmortem human histology and connectional anatomy inferred from nonhuman primates. This structure/function correspondence in resting-state activity was strongest between each cerebral hemisphere and its ipsilateral thalamus. However, each hemisphere was also strongly correlated with the contralateral thalamus, a pattern that is not attributable to known thalamocortical monosynaptic connections. These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting- state fMRI BOLD imaging to elucidate thalamocortical relationships.