Serotonin transporter genotype moderates the link between children's reports of overprotective parenting and their behavioral inhibition.
Serotonin transporter genotype moderates the link between children's reports of overprotective parenting and their behavioral inhibition.
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血清素转运蛋白基因型调节了儿童过度保护性养育与其行为抑制之间的联系。
DOI：
10.1007/s10802-011-9526-2
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发表时间：
2011
影响因子：
3.6
通讯作者：
McGeary,JohnE
中科院分区：
文献类型：
--
作者：
Burkhouse,KatieL;Gibb,BrandonE;Coles,MeredithE;Knopik,ValerieS;McGeary,JohnE
当前研究的目的是检查儿童行为抑制（BI）水平的环境和遗传相关性。参与者是来自社区的100对母子，他们是一项关于抑郁症代际传播的大型研究的一部分。结果表明，正如儿童所报告的那样，较高水平的母亲过度保护与携带两个低表达5-HTTLPR等位基因拷贝（S或LG）的儿童的BI升高有关，但与仅携带一个拷贝或lallpr等位基因纯合子的儿童无关。此外，这种交互作用是特定于BI的社会成分，而不是非社会成分。即使在对儿童和母亲的精神病理进行统计控制后，这种关系仍然存在。总之，这些发现增加了新兴研究，表明gxe相互作用预测儿童时期BI的变化。
The goal of the current study was to examine environmental and genetic correlates of children’s levels of behavioral inhibition (BI). Participants were 100 mother child pairs drawn from the community who were part of a larger study of the intergenerational transmission of depression. Results indicated that higher levels of maternal overprotection, as reported by the child, were associated with elevations in BI among children carrying two copies of the lower expressing 5-HTTLPR alleles (S or LG), but not among those carrying only one copy or those homozygous for the LAallele. In addition, this interaction was specific for the social component of BI, not the nonsocial component. This relation was maintained even after statistically controlling for children’s and mother’s psychopathology. Together, these findings add to emerging research demonstrating that G × E interactions predict variation in BI during childhood.