Functional and anatomic organization of three-dimensional eye movements in rabbit cerebellar flocculus.
Functional and anatomic organization of three-dimensional eye movements in rabbit cerebellar flocculus.
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兔小脑絮球三维眼球运动的功能和解剖组织。
DOI：
10.1152/jn.1994.72.1.31
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发表时间：
1994
影响因子：
2.5
通讯作者：
Tan,J
中科院分区：
文献类型：
--
作者：
VanderSteen,J;Simpson,JI;Tan,J
1.用巩膜探测线圈技术记录了电微刺激警觉有色家兔小脑小叶诱发的三维双眼眼球运动。这些眼球运动的分量是参考由垂直轴和两个水平轴组成的正交坐标系在45度和135度方位角获得的。方位角坐标从0度参考点向机头方向两侧增加。2.眼动最容易被刺激诱发（0.2 ms脉冲，200 Hz，1 s，强度≤ 20 microA），在深颗粒层和白色物质的位点。它们由缓慢（5-20度/秒）运动组成。反应是双眼的，与同侧的眼睛刺激的小叶通常具有较大的幅度，或单眼的，在这种情况下，他们被限制在同侧的眼睛。3.根据双眼最大测量旋转分量及其旋转方向（顺时针，CW或逆时针，CCW）的组合对诱发反应进行分类。78%的诱发眼动可分为两类.对于这些类别之一，最大的反应成分是同侧眼睛围绕其垂直轴的短潜伏期外展（19%），而对于另一类（59%），最大的反应成分是同侧（左）眼睛围绕其135度轴的短潜伏期CCW旋转.这种反应经常（50%）伴随着对侧（右）眼睛围绕其45度轴的较小的短潜伏期CW旋转。4.两个主要类别的三维眼球运动与乙酰胆碱酯酶组织化学揭示的解剖学上可区分的隔室差异相关。在絮状白色物质的五个解剖学上可区分的隔室中，三个是主要的。这三个隔室的中间与垂直轴类的运动相关联，而两个相邻隔室与135度类的眼睛运动相关联。其他两个较小的隔室的眼动关系未确定。5.诱发眼运动的两个主要类别的旋转轴的空间取向密切对应的视觉攀爬纤维输入到小叶的优选轴。这表明两者都是在类似的坐标系中组织的。（400字处截断摘要）
1. The three -dimensional, binocular eye movements evoked by electrical microstimulation of the cerebellar flocculus of alert, pigmented rabbits were recorded using the scleral search coil technique. The components of these eye movements were obtained in reference to an orthogonal coordinate system consisting of a vertical axis and two horizontal axes at 45 degrees and 135 degrees azimuth. The azimuth coordinate was taken to increase to both sides from the 0 degrees reference in the direction of the nose. 2. Eye movements were evoked most readily by stimulation (0.2 -ms pulses at 200 Hz for 1 s, intensity < or = 20 microA) at loci in the deep granular layer and the white matter. They consisted of slow (5–20 deg/s) movements. The responses were either binocular, with the eye ipsilateral to the stimulated flocculus usually having the larger amplitude, or were monocular, in which case they were restricted to the ipsilateral eye. 3. The evoked responses were classified according to the combination of the largest measured component of rotation for the two eyes and its sense of rotation (clockwise, CW, or counterclockwise, CCW). Seventy -eight percent of the evoked eye movements could be placed in one of two classes. For one of these classes the largest response component was a short -latency abduction of the ipsilateral eye about its vertical axis (19%), whereas for the other class (59%), the largest response component was a short -latency CCW rotation of the ipsilateral (left) eye about its 135 degrees axis. This response was frequently (50%) accompanied by a smaller short -latency CW rotation of the contralateral (right) eye about its 45 degrees axis. 4. The two main classes of three -dimensional eye movements are associated differentially with anatomically distinguishable compartments that are revealed by acetylcholinesterase histochemistry. Of the five anatomically distinguishable compartments in the floccular white matter, three are predominant. The middle of these three compartments is associated with the vertical axis class of movements, whereas the two adjacent compartments are associated with the 135 degrees class of eye movements. The eye movement relation of the other two, smaller compartments, was not determined. 5. The spatial orientation of the rotation axes of the two main classes of evoked eye movements closely corresponds to that of the preferred axes of the visual climbing fiber input to the flocculus. This suggests that both are organized in a similar coordinate system.(ABSTRACT TRUNCATED AT 400 WORDS)