A Frequency Translation System for Multi-Channel, Multi-Nuclear MR Spectroscopy.
A Frequency Translation System for Multi-Channel, Multi-Nuclear MR Spectroscopy.
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DOI：
10.1109/tbme.2020.2997770
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Wright SM
中科院分区：
文献类型：
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作者：
Ogier SE;Wilcox M;Cheshkov S;Dimitrov IE;Malloy CR;McDougall MP;Wright SM
大多数MRI扫描仪都配备了接收来自1H阵列线圈的信号，但很少支持多通道接收其他核的信号。使用接收阵列可以提供显著的信噪比优势，通常用于加速成像，但由于宽带阵列接收器的相对缺乏，将这些阵列扩展到非1h核受到的关注较少。非1h核通常具有较低的灵敏度，并且可以从阵列可以提供的信噪比的增加中受益匪浅。本文提出了一种经济有效的方法，使标准1H多通道阵列接收器与其他核一起使用-在这种情况下，是13C。已经开发了一种频率转换系统，该系统使用位于磁孔处的有源混频器将接收到的信号从非1H阵列转换为由主机系统接收器接收的1H频率。该系统已在4.7T和7T下进行了验证，同时保持了信噪比和隔离度。对13C检测特别重要的1H去耦可以直接调节。频率转换可以将仅h多通道接收器转换为与其他核一起使用，同时保持信噪比和通道隔离，同时仍然启用1H去耦。这项工作允许现有的多通道MRI接收器适应于接收来自1H以外核的信号，允许使用体内多核磁共振的接收阵列。
Most MRI scanners are equipped to receive signals from 1H array coils but few support multi-channel reception for other nuclei. Using receive arrays can provide significant SNR benefits, usually exploited to enable accelerated imaging, but the extension of these arrays to non-1H nuclei has received less attention because of the relative lack of broadband array receivers. Non-1H nuclei often have low sensitivity and stand to benefit greatly from the increase in SNR that arrays can provide. This paper presents a cost-effective approach for adapting standard 1H multi-channel array receivers for use with other nuclei – in this case, 13C. A frequency translation system has been developed that uses active mixers residing at the magnet bore to convert the received signal from a non-1H array to the 1H frequency for reception by the host system receiver. This system has been demonstrated at 4.7T and 7T while preserving SNR and isolation. 1H decoupling, particularly important for 13C detection, can be straightforwardly accommodated. Frequency translation can convert 1H-only multi-channel receivers for use with other nuclei while maintaining SNR and channel isolation while still enabling 1H decoupling. This work allows existing multi-channel MRI receivers to be adapted to receive signals from nuclei other than 1H, allowing for the use of receive arrays for in vivo multi-nuclear NMR.