Statistical parametric mapping:: Assessment of application in children
Statistical parametric mapping:: Assessment of application in children
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DOI：
10.1006/nimg.2000.0651
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发表时间：
2000-11-01
期刊：
影响因子：
5.7
通讯作者：
Chugani, HT
中科院分区：
文献类型：
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作者：
Muzik, O;Chugani, DC;Chugani, HT
SPM是一种功能强大的技术，用于比较患者组之间的功能成像数据集。虽然这种技术已被广泛应用于成人的研究，它很少被应用于儿童的研究，部分原因是缺乏验证的空间归一化程序在不同年龄的儿童。为了确定使用SPM 96到成人模板的FDG PET图像的空间归一化是否可以成功地应用于儿童，我们将PET衍生的变换参数应用于共配准的MRI图像。然后，我们比较了13名癫痫儿童（年龄2-14岁，平均7.6 ± 3.9岁）与17名成人对照（平均年龄27.6 ± 4.5岁）的空间标准化MRI图像的轮廓。从儿科组获得的空间标准化MRI图像体积的轮廓比从成人对照组获得的轮廓变化更大。与成人平均轮廓的平均偏差随年龄增长而减小（平均偏差（mm）= 2.22（mm）- 0.021（mm/年）×年，r = 0.70，P < 0.001）。对6岁以下儿童（N-1 = 6）和6至14岁儿童（N-2 = 7）进行单独SPM分析。在两个儿科组中进行的SPM分析显示，与癫痫灶一致的位置存在显著的低代谢区域。年轻组的SPM分析也显示出显著的伪影。因此，在小于6岁的儿童中，与儿童大脑到成人模板的空间标准化相关的误差排除了在该年龄组中应用统计参数映射。尽管6至14岁儿童的空间标准化程序中的误差高于成人，但似乎该误差不会导致SPM分析中的伪影。此外，与我们先前的研究显示青春期绝对葡萄糖代谢率的年龄相关变化相反，SPM分析显示6岁以上的儿童似乎显示出与成人相同的葡萄糖利用模式。然而，由于样本量的原因，可能未检测到儿童晚期和青春期可能发生的葡萄糖利用模式的微小差异。(C)北京大学出版社.
SPM is a powerful technique for the comparison of functional imaging data sets among groups of patients. While this technique has been widely applied in studies of adults, it has rarely been applied to studies of children, due in part to the lack of validation of the spatial normalization procedure in children of different ages. In order to determine if spatial normalization of FDG PET images using SPM96 to an adult template can be successfully applied in children, we applied PET-derived transformation parameters to coregistered MRI images. We then compared contours of spatially normalized MRI images obtained from 13 children with epilepsy (ages 2-14 years, mean 7.6 +/- 3.9 years) with those derived from 17 adult controls (mean age 27.6 +/- 4.5 years). Contours of spatially normalized MRI image volumes derived from the pediatric group were more variable than those obtained from adult controls. The average deviation from the mean adult contour was age-dependent and decreased with age (average deviation (mm) = 2.22 (mm) - 0.021 (mm/year) x years, r = 0.70,P < 0.001). Separate SPM analyses were performed for children less than 6 years (N-1 = 6) and for children between 6 and 14 years of age (N-2 = 7). SPM analyses performed in both pediatric groups showed significant regions of hypometabolism in locations consistent with their epileptic foci. SPM analyses in the younger group also showed significant artifacts. Therefore, the error associated with spatial normalization of pediatric brains to an adult template in children less than 6 years of age precludes the application of statistical parametric mapping in this age group, Although the error in the spatial normalization procedure for children ages 6 to 14 years is higher than in adults, it appears that this error does not result in artifacts in the SPM analysis. Furthermore, in contrast our previous studies showing large age-related changes in the absolute glucose metabolic rate at puberty, the SPM analysis showed children over 6 years of age appear to display the same pattern of glucose utilization as adults. However, small differences in the pattern of glucose utilization which might occur during late childhood and adolescence may not have been detected due to the sample size. (C) 2000 Academic Press.