Which is most pungent: isoflurane, sevoflurane or desflurane?
Which is most pungent: isoflurane, sevoflurane or desflurane?
复制标题
异氟烷、七氟烷或地氟烷哪个最刺激？
DOI：
--
复制
发表时间：
2000
影响因子：
9.8
通讯作者：
Martin I. Gold
中科院分区：
文献类型：
--
作者：
M. TerRiet;G. DeSouza;Jeffrey S. Jacobs;D. Young;Michael C. Lewis;C. Herrington;Martin I. Gold
我们在一项随机、双盲研究中比较了三种吸入麻醉剂的刺激性和耐受性。81例未术前用药患者（每组n = 27）通过面罩从麻醉呼吸回路吸入2 MAC异氟烷（2.3%）、地氟烷（12%）或七氟烷（4%），持续60 s。两名设盲观察员记录咳嗽、烧灼感和刺激症状以及吸入耐受时间。一名七氟烷患者咳嗽，但完成了研究期，而11名异氟烷患者和20名地氟烷患者咳嗽，口头反对或用力摘下面罩。所有七氟醚、20例异氟醚和7例地氟醚患者完成了研究期（平均分别为60、49和33 s，P < 0.05）。应激反应分级为地氟醚>异氟醚>七氟醚（P < 0.05）。在2 MAC浓度下，七氟烷是吸入刺激性最小的药物。
We compared the pungency and tolerability of three inhaled anaesthetics in a randomized, double-blind study. Eighty-one unpremedicated patients (n = 27, each group) inhaled 2 MAC of isoflurane (2.3%), desflurane (12%) or sevoflurane (4%) for 60 s from an anaesthetic breathing circuit via a mask. Two blinded observers recorded coughing, complaints of burning and irritation, and how long the inhalation was tolerated. One sevoflurane patient coughed, but completed the study period, whereas 11 isoflurane patients and 20 desflurane patients coughed, objected verbally or removed the mask forcefully. All sevoflurane, 20 isoflurane and seven desflurane patients completed the study period (average 60, 49 and 33 s, respectively, P < 0.05). The irritability grading was: desflurane > isoflurane > sevoflurane (P < 0.05). Sevoflurane is the least irritating agent for inhalation at 2 MAC concentration.