hamlet, a binary genetic switch between single- and multiple-dendrite neuron morphology
hamlet, a binary genetic switch between single- and multiple-dendrite neuron morphology
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DOI：
10.1126/science.1072387
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发表时间：
2002-08-23
期刊：
影响因子：
56.9
通讯作者：
Jan, YN
中科院分区：
文献类型：
--
作者：
Moore, AW;Jan, LY;Jan, YN
神经元的树突形态决定了它们接受的输入的数量和类型。在果蝇周围神经系统(PNS)中，外部感觉(ES)神经元只有一个非分枝的树突，而线形相关的多树突(MD)神经元具有广泛的树枝分枝。我们报道，哈姆雷特是这些不同形态类型之间的二元遗传开关。在Hamlet突变体中，ES神经元转化为MD命运，而在MD前体中异位表达的Hamlet导致MD神经元向ES神经元转化。此外，在经历树突生长的MD神经元中诱导HAMLET的表达显著减少了Arbor分支。
The dendritic morphology of neurons determines the number and type of inputs they receive. In the Drosophila peripheral nervous system ( PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally related multidendritic ( MD) neurons have extensively branched dendritic arbors. We report that hamlet is a binary genetic switch between these contrasting morphological types. In hamlet mutants, ES neurons are converted to an MD fate, whereas ectopic hamlet expression in MD precursors results in transformation of MD neurons into ES neurons. Moreover, hamlet expression induced in MD neurons undergoing dendrite outgrowth drastically reduces arbor branching.