Experiments in searching small proteins in unannotated large eukaryotic genomes
Experiments in searching small proteins in unannotated large eukaryotic genomes
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DOI：
10.1021/pr049811i
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发表时间：
2005-01-01
影响因子：
4.4
通讯作者：
Bougueleret, L
中科院分区：
文献类型：
--
作者：
Colinge, J;Cusin, I;Bougueleret, L
人们对使用质谱学数据直接搜索基因组序列的兴趣越来越大。其他作者之前的工作表明，这种方法能够纠正和补充现有的基因组注释。我们讨论了用小蛋白的多肽离子陷阱串联质谱学搜索大的真核基因组的实际困难。
There is growing interest to use mass spectrometry data to search genome sequences directly. Previous work by other authors demonstrated that this approach is able to correct and complement available genome annotations. We discuss the practical difficulty of searching large eukaryotic genomes with peptide ion trap tandem mass spectra of small proteins (