Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor
Susceptibility of epithelial cells to Pseudomonas aeruginosa invasion and cytotoxicity is upregulated by hepatocyte growth factor
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DOI：
10.1128/iai.66.7.3443-3446.1998
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发表时间：
1998-07-01
影响因子：
3.1
通讯作者：
Mostov, KE
中科院分区：
文献类型：
--
作者：
Fleiszig, SMJ;Vallas, V;Mostov, KE
正常的细胞极性保护上皮细胞免受铜绿假单胞菌的入侵和细胞毒性。使用具有选择性缺陷的上皮细胞克隆对膜成分进行分选，并使用肝细胞生长因子预处理，我们发现可以在不破坏紧密连接的情况下改变对铜绿假单胞菌的极化敏感性。结果还表明，侵袭和细胞毒性的细胞易感性因素不同，尽管两者都定位于极化上皮细胞的基底外侧细胞表面。
Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered without disrupting tight junctions. The results also showed that cellular susceptibility factors for invasion and cytotoxicity are not the same, although both are localized to the basolateral cell surface in polarized epithelial cells.