A Novel and Efficient Model of Coronary Artery Ligation in the Mouse
A Novel and Efficient Model of Coronary Artery Ligation in the Mouse
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DOI：
10.1007/978-1-62703-505-7_17
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Koch, Walter J.
中科院分区：
文献类型：
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作者：
Gao, Erhe;Koch, Walter J.
冠状动脉结扎诱导小鼠心肌梗死(MI)和缺血/再灌注(I/R)损伤的典型方法是一种有创且耗时的方法，需要进行机械通气和全开胸手术(经典方法)，通常会导致广泛的组织损伤和高死亡率。在这里，我们描述了一种新的、快速的外科方法来诱导不需要通风的心肌梗死。这种方法比经典的MI和I/R损伤方法更有效、更安全。
Coronary artery ligation to induce myocardial infarction (MI) and ischemia/reperfusion (I/R) injury in mice is typically performed by an invasive and time-consuming approach that requires ventilation and a full thoracotomy (classical method), often resulting in extensive tissue damage and high mortality. Here, we describe a novel and rapid surgical method to induce MI that does not require ventilation. This method is much more efficient and safer than the classical method of MI and I/R injury.