IS THE BRAIN "AN IMMUNOLOGICALLY PRIVILEGED SITE"?I. STUDIES BASED ON INTRACEREBRAL TUMOR HOMOTRANSPLANTATION AND ISOTRANSPLANTATION TO SENSITIZED HOSTS.
IS THE BRAIN "AN IMMUNOLOGICALLY PRIVILEGED SITE"?I. STUDIES BASED ON INTRACEREBRAL TUMOR HOMOTRANSPLANTATION AND ISOTRANSPLANTATION TO SENSITIZED HOSTS.
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大脑是“免疫学上的特权部位”吗？
DOI：
10.1001/archneur.1964.00460210026003
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发表时间：
1964
影响因子：
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通讯作者：
W. A. Levy
中科院分区：
文献类型：
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作者：
L. Scheinberg;F. Edelman;W. A. Levy
前言大脑在受到脑内异种组织植入的挑战时，未能做出典型的免疫反应，这引起了研究人员的兴趣，并引发了相当大的猜测。Medaw1显示，当同种皮肤被植入大脑时，大脑在组织学上不会产生典型的“初级或次级集合反应”。Greene2-4表明，大脑将接受肿瘤同种或异种移植。这些现象和未能证明大脑中的淋巴通道导致了大脑是“免疫特权部位”的概念。本报告的目的主要是介绍进一步审查这一概念的一些调查的结果。然而，当将肿瘤同种移植或同种移植移植到实验动物的大脑中时，组织学事件的知识也可能被证明对理解人脑对
Introduction The failure of the brain to respond with a typical immune reaction when challenged by intracerebral implantation of nonisologous tissue has intrigued investigators and led to considerable speculation. Medawar1showed that the brain does not respond with the typical "primary or secondary set reaction" histologically when homologous skin is implanted in the cerebrum. Greene2-4demonstrated that the brain will accept tumor homotransplants or heterotransplants. These phenomena and the failure to demonstrate lymphatic channels in the brain have led to the concept that the brain is "an immunologically privileged site." The purpose of this report primarily is to present results of some investigations that further examine this concept. However, knowledge of the histologic events which occur when a tumor homotransplant or isotransplant is placed in the brain of the experimental animal may also prove useful in the understanding of the mechanisms by which the human brain reacts to