Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?
Targeting peroxisome proliferator-activated receptor-β/δ in colon cancer: how to aim?
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在结肠癌中靶向过氧化物酶体增殖物激活的受体-β/δ：如何瞄准？
DOI：
10.1016/j.bcp.2012.09.031
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发表时间：
2013-03-01
影响因子：
5.8
通讯作者：
Shureiqi, Imad
中科院分区：
文献类型：
--
作者：
Xu, Min;Zuo, Xiangsheng;Shureiqi, Imad
Peroxisome proliferator-activated receptor-β/δ (PPARδ) is a ubiquitously expressed, ligand-activated transcriptional factor that performs diverse critical functions in normal cells (e.g., fatty acid metabolism, obesity, apoptosis, and inflammation). Various studies in humans have found that PPARδ is upregulated in primary colorectal cancers; however, these findings have been challenged by those of other reports. Similarly, various in vitro and in vivo mechanistic pre-clinical models have yielded data demonstrating that PPARδ promotes colonic tumorigenesis, but other models have yielded data that contradicts this notion. Definitive studies are therefore needed to establish the exact role of PPARδ in human colorectal tumorigenesis and to provide a theoretical basis for PPARδ therapeutic targeting.
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体重对人结直肠癌中核受体和环氧酶-2的表达改变的影响。
影响因子：
5.4
作者：
Delage B;Rullier A;Capdepont M;Rullier E;Cassand P
通讯作者：
Cassand P
DOI：
10.1073/pnas.091021198
发表时间：
2001-04-24
影响因子：
11.1
作者：
Oliver, WR;Shenk, JL;Willson, TM
通讯作者：
Willson, TM
DOI：
10.1073/pnas.012610299
发表时间：
2002-01-08
影响因子：
11.1
作者：
Barak, Y;Liao, D;Evans, RM
通讯作者：
Evans, RM
影响因子：
11.2
作者：
Liou, Jun-Yang;Ghelani, Dipak;Wu, Kenneth K.
通讯作者：
Wu, Kenneth K.
影响因子：
16
作者：
Barak, Y;Nelson, MC;Evans, RM
通讯作者：
Evans, RM