Long-term outcome after resection for recurrent oesophageal cancer
Long-term outcome after resection for recurrent oesophageal cancer
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DOI：
10.21037/jtd.2018.05.17
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发表时间：
2018-05-01
影响因子：
2.5
通讯作者：
Tachimori, Yuji
中科院分区：
文献类型：
--
作者：
Kato, Fumihiko;Monma, Satoko;Tachimori, Yuji
背景：食管癌淋巴结（LN）或远处复发的手术切除的疗效尚未得到充分研究。本研究的目的是揭示适当的适应症的手术approximates.Methods：共42例手术后复发或残留食管鳞状细胞癌切除术或明确的放化疗（dCRT）之间2004年4月至2016年8月确定。这些切除术不包括挽救性食管切除术。结果：33例患者行LN切除术，6例患者行肺切除术，3例患者因其他复发肿瘤而切除。在dCRT后接受挽救性腹部淋巴结清扫术的患者的5年总生存率（OS）明显优于接受挽救性颈部或纵隔淋巴结清扫术的患者（46.9% vs. 0.0%，P=0.006）。在放射野外接受淋巴结挽救性切除术的患者的5年OS显著优于在放射野内接受切除术的患者（47.6% vs. 8.9%，P=0.027）。因复发淋巴结行挽救性切除术的患者的5年OS明显优于因残留淋巴结行挽救性切除术的患者（21.7% vs. 0.0%，P
Background: The efficacy of surgical resection for lymph node (LN) or distant recurrence of oesophageal cancer has not been sufficiently investigated. The objective of this study was to reveal appropriate indications for a surgical approach.Methods: A total of 42 patients who underwent resection for recurrent or residual oesophageal squamous cell carcinoma after surgery or definitive chemoradiotherapy (dCRT) between April 2004 and August 2016 were identified. These resections did not include salvage oesophagectomy. The long-term outcomes of these patients were retrospectively analysed.Results: Thirty-three patients underwent LN resection, 6 patients underwent lung resection, and 3 patients underwent resection for other recurrent tumours. The 5-year overall survival (OS) of patients who underwent salvage abdominal lymphadenectomy after dCRT was significantly better than that of patients who underwent salvage cervical or mediastinal lymphadenectomy (46.9% vs. 0.0%, P=0.006). The 5-year OS of patients who underwent salvage resection for LNs outside the radiation field was significantly better than that of patients who underwent resection inside the radiation field (47.6% vs. 8.9%, P=0.027). The 5-year OS of patients who underwent salvage resection for recurrent LNs was significantly better than that of patients who underwent salvage resection for residual LNs (21.7% vs. 0.0%, P