Mechanistic studies by sum-frequency generation spectroscopy: hydrolysis of a supported phospholipid bilayer by phospholipase A2.

Mechanistic studies by sum-frequency generation spectroscopy: hydrolysis of a supported phospholipid bilayer by phospholipase A2.
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DOI:
10.1002/anie.200904950
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发表时间:
2010-03
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通讯作者:
Yujin Tong;Na Li;Huijin Liu;Aimin Ge;M. Osawa;S. Ye
Yujin Tong;Na Li;Huijin Liu;Aimin Ge;M. Osawa;S. Ye
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作者:
Yujin Tong;Na Li;Huijin Liu;Aimin Ge;M. Osawa;S. Ye

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(图)母亲们的总和:和频发生光谱用于研究磷脂酶A2(PLA 2)对二棕榈酰磷脂酰胆碱双分子层的水解机制。本研究从分子水平上描述了支撑脂质双层的每个小叶(红色和黑色)的结构变化和水解机制。
(Figure Presented) Sum mothers do'ave'em: Sum-frequency generation spectroscopy was used to investigate the hydrolysis mechanism of a dipalmitoylphosphatidylcholine bilayer by phospholipase A 2 (PLA 2). This study describes the structural changes and the hydrolysis mechanism in each leaflet (red and black) of a supported lipid bilayer at a molecular level.