Intraoperative monitoring of blood perfusion in port wine stains by laser Doppler imaging during vascular targeted photodynamic therapy: A preliminary study
Intraoperative monitoring of blood perfusion in port wine stains by laser Doppler imaging during vascular targeted photodynamic therapy: A preliminary study
复制标题
DOI：
10.1016/j.pdpdt.2016.04.002
复制
发表时间：
2016-06-01
影响因子：
3.3
通讯作者：
Gu, Ying
中科院分区：
文献类型：
--
作者：
Chen, Defu;Ren, Jie;Gu, Ying
目的：应用激光多普勒成像(LDI)技术对鲜红斑痣患者进行血管靶向光动力疗法(V-PDT)时的血流动力学变化进行监测。方法：对30例面部PWS患者进行V-PDT治疗，并以5例健康人前臂正常皮肤作为对照。此外，3例PWS患者的同一个体的两个不同的PWS皮损分别接受了单纯激光照射和V-PDT。结果：33例PWS患者接受V-PDT治疗后，31例PWS患者的PWS病灶血流灌注量(278+/-96PU)在治疗开始后明显增加，10min内达到峰值(638+/-105PU)，随后缓慢下降至相对较低水平(515+/-100PU)。此外，血液灌注量达到峰值的时间和随后下降的幅度因患者而异。在单纯光照的对照组中，无论是在正常皮肤还是在PWS病变中，LDI均在3min出现一次血流灌注峰值，随后出现最低值和继发性升高。结论：初步结果表明，LDI可以无创性地监测PWS病变在V-PDT中的血流灌注变化。在V-PDT和激光照射过程中，血流灌注反应有明显的变化趋势。治疗过程中血液灌注量的变化是由于V-PDT效应和激光照射引起的局部温度升高所致。(C)2016爱思唯尔B.V.保留所有权利。
Objective: The objective of this study was to monitor blood perfusion dynamics of port wine stains (PWS) during vascular targeted photodynamic therapy (V-PDT) with laser Doppler imaging (LDI).Methods: The PWS lesions of 30 facial PWS patients received V-PDT, while the normal skins on the forearm of 5 healthy subjects were treated as light-only controls for comparison. Furthermore, two different PWS lesions in the same individual from each of 3 PWS patients successively received laser irradiation only and V-PDT, respectively. LDI was used to monitor intraoperative blood perfusion dynamics.Results: During V-PDT, the blood perfusion (278 +/- 96 PU) in PWS lesions for 31 of 33 PWS patients significantly increased after the initiation of V-PDT treatment, then reached a peak (638 +/- 105 PU) within 10 min, followed by a slow decrease to a relatively lower level (515 +/- 100 PU). Furthermore, the time for reaching peak and the subsequent magnitude of decrease in blood perfusion varied with different patients. For light-only controls, an initial perfusion peak at 3 min followed by a nadir and a secondary increase were found not only in normal skin, but also in PWS lesions.Conclusion: The preliminary results showed that the LDI permits non-invasive monitoring blood perfusion changes of PWS lesions during V-PDT. There was a clear trend in blood perfusion responses during V-PDT and laser irradiation. The blood perfusion changes during treatment were due to V-PDT effects as well as local temperature increase induced by laser irradiation. (C) 2016 Elsevier B.V. All rights reserved.