Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats
Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats
复制标题
DOI：
10.1016/s0378-4274(98)00035-6
复制
发表时间：
1998-05-01
影响因子：
3.5
通讯作者：
Maur, GB
中科院分区：
文献类型：
--
作者：
Deshpande, SS;Lalitha, VS;Maur, GB
对雌性瑞士小鼠和 Wistar 大鼠通过饮食喂食姜黄（0、1 和 5%）和乙醇姜黄提取物（0、0.05 和 0.25%）14 和/或 90 天，研究了姜黄和乙醇姜黄提取物的亚慢性口服毒性。在小鼠和大鼠中，长时间（90天）施用高剂量（5%）姜黄可显着减少体重增加、绝对和/或相对肝脏重量的改变以及肝毒性，即局灶性坏死或局灶性坏死伴再生。在小鼠中，较低剂量的姜黄（即 0.2 或 1%，持续 14 天）也显示出肝毒性，并且发现它们比大鼠更容易受到姜黄诱导的肝毒性的影响。 (C) 1998 Elsevier Science Ireland Ltd. 保留所有权利。
Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed a significant reduction in body weight gain, alterations in absolute and/or relative liver weights, and hepatotoxicity i.e. focal necrosis or focal necrosis with regeneration both in mice and rats. In mice lower doses of turmeric i.e 0.2 or 1% for 14 days also showed hepatotoxicity and they were found to be more vulnerable to turmeric-induced hepatotoxicity than rats. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.