Effects of White-Matter Tract Length in Sport-Related Concussion: A Tractography Study from the NCAA-DoD CARE Consortium.
Effects of White-Matter Tract Length in Sport-Related Concussion: A Tractography Study from the NCAA-DoD CARE Consortium.
复制标题
白质纤维束长度对运动相关脑震荡的影响：来自 NCAA-DoD CARE 联盟的纤维束描记术研究。
DOI：
10.1089/neu.2021.0239
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发表时间：
2022
影响因子：
4.2
通讯作者：
McAllister
中科院分区：
文献类型：
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作者：
Mustafi,SourajitM;Yang,Ho-Ching;Harezlak,Jaroslaw;Meier,TimothyB;Brett,BenjaminL;Giza,ChristopherC;Goldman,Joshua;Guskiewicz,KevinM;Mihalik,JasonP;LaConte,StephenM;Duma,StefanM;Broglio,StevenP;McCrea,MichaelA;McAllister
运动相关脑震荡（SRC）是一个重要的公共卫生问题。 SRC 后的白质改变通过神经影像学方法（例如扩散磁共振成像 (MRI)）进行了广泛研究。尽管改变的确切解剖位置可能有所不同，但在长纤维束中通常观察到显着的白质改变，但从未得到证实。在本研究中，我们进行了流线纤维束成像，以表征 SRC 后纤维束长度与白质微结构改变之间的关联。本研究纳入了 68 名被诊断患有急性脑震荡（受伤后 24-48 小时）的大学运动员和 64 名匹配的接触运动对照者。运动员在三个研究地点的 3.0 T MRI 扫描仪中接受了扩散张量成像 (DTI)。 DTI 指标用于基于区域的空间统计，以绘制具有显着组间差异的白质感兴趣区域 (ROI)。进行全脑白质流线束成像以提取“受影响的”白质流线（即穿过已识别的 ROI 的流线）。在脑震荡的运动员中，对受影响的白质纤维束的流线计数和 DTI 指标进行了总结，并与同一参与者的不同纤维束长度上未受影响的白质纤维束进行了比较。受影响的白质束在长度为 80-100mm 时具有较高的流线计数，并且对于流线长度超过 80mm 的长度调整受影响比较高。在长度超过 100mm 的受影响流线中，DTI 平均扩散率较高，与简短症状清单评分显着相关。我们的研究结果表明，与整个分布相比，大学运动员大脑中的长纤维更容易受到急性 SRC 的影响，其平均扩散率和受影响比率更高。
Sport-related concussion (SRC) is an important public health issue. White-matter alterations after SRC are widely studied by neuroimaging approaches, such as diffusion magnetic resonance imaging (MRI). Although the exact anatomical location of the alterations may differ, significant white-matter alterations are commonly observed in long fiber tracts, but are never proven. In the present study, we performed streamline tractography to characterize the association between tract length and white-matter microstructural alterations after SRC. Sixty-eight collegiate athletes diagnosed with acute concussion (24–48 h post-injury) and 64 matched contact-sport controls were included in this study. The athletes underwent diffusion tensor imaging (DTI) in 3.0 T MRI scanners across three study sites. DTI metrics were used for tract-based spatial statistics to map white-matter regions-of-interest (ROIs) with significant group differences. Whole-brain white-mater streamline tractography was performed to extract “affected” white-matter streamlines (i.e., streamlines passing through the identified ROIs). In the concussed athletes, streamline counts and DTI metrics of the affected white-matter fiber tracts were summarized and compared with unaffected white-matter tracts across tract length in the same participant. The affected white-matter tracts had a high streamline count at length of 80–100 mm and high length-adjusted affected ratio for streamline length longer than 80 mm. DTI mean diffusivity was higher in the affected streamlines longer than 100 mm with significant associations with the Brief Symptom Inventory score. Our findings suggest that long fibers in the brains of collegiate athletes are more vulnerable to acute SRC with higher mean diffusivity and a higher affected ratio compared with the whole distribution.