Nutritional and Immunological Correlates of Memory and Neurocognitive Development Among HIV-Infected Children Living in Kayunga, Uganda.
Nutritional and Immunological Correlates of Memory and Neurocognitive Development Among HIV-Infected Children Living in Kayunga, Uganda.
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生活在乌干达卡永加的艾滋病毒感染儿童的记忆和神经认知发展的营养和免疫相关性。
DOI：
10.1097/qai.0000000000000905
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Boivin,Michael
中科院分区：
文献类型：
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作者：
Ruiseñor-Escudero,Horacio;Familiar-Lopez,Itziar;Sikorskii,Alla;Jambulingam,Nikita;Nakasujja,Noelline;Opoka,Robert;Bass,Judith;Boivin,Michael
Objective:To identify the nutritional and immunological correlates of memory and neurocognitive development as measured by the Mullen Scales of Early Learning (MSEL) and by the Color Object Association Test (COAT) among children in Uganda.Design:This analysis uses baseline data collected between 2008 and 2010 from 119 HIV-infected children aged 1–6 years, participating in a randomized controlled trial of an interventional parenting program in Kayunga, Uganda.Methods:Peripheral blood draws were performed to determine immunological biomarkers. Unadjusted and adjusted linear regression models were used to relate MSEL and COAT scores to sociodemographic characteristics, weight-for-age Z scores (WAZs), antiretroviral therapy status, and immunological biomarkers.Results:In the final analysis, 111 children were included. Lower levels of CD4+ CD38+ T cells (P= 0.04) were associated to higher immediate and total recall scores (P= 0.04). Higher levels of CD8+ HLA-DR+ T cells were associated with higher total recall score (P= 0.04) of the COAT. Higher CD4+ CD38+ HLA-DR+ T cells levels were associated with higher gross motor scores of the MSEL (P= 0.02). WAZ was positively correlated to visual reception, fine motor, expressive language, and composite score of the MSEL.Conclusions:Overall, WAZ was a stronger predictor of neurocognitive outcomes assessed by the MSEL. CD4+ CD38+ T cells were more specifically associated with memory-related outcomes. Future research should include immunological markers and standardized neurocognitive tests to further understand this relationship.
