Benzyl salicylate: a survey of consumer patch-test sensitization.
Benzyl salicylate: a survey of consumer patch-test sensitization.
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水杨酸苄酯：消费者斑贴试验致敏性调查。
DOI：
10.1016/0278-6915(83)90206-5
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
G. R. Thompson
中科院分区：
文献类型：
--
作者：
K. A. Kohrman;K. Booman;J. Dorsky;A. Rothenstein;R. Sedlak;R. J. Steltenkamp;G. R. Thompson
水杨酸苄酯是一种重要的香料和风味成分，通过分析斑贴试验数据，评估了它在普通人群中引起过敏或引起对已有过敏反应的可能性。从香精和配方公司获得的总共10,538个斑贴试验的结果，对各种家用和个人护理消费品以及含有水杨酸苄的香精混合物进行了分析，作为本调查的一部分。在单独对水杨酸苄进行的35次斑贴试验中，或对含有水杨酸苄的消费品或香水混合物进行的10,503次斑贴试验中，均未观察到直接由水杨酸苄引起的诱导或诱发反应。在消费品试验中测试的水杨酸苄酯的最高浓度为2 × 10 - 1%，单独测试的水杨酸苄酯在乙醇中的浓度为10%。该研究表明，水杨酸苄酯诱导超敏反应（“诱导”反应）或引发可能归因于预先存在的致敏反应（“诱发”反应）的可能性非常低，因此支持水杨酸苄酯在消费品和香料混合物中的安全使用。
The potential of benzyl salicylate, an important fragrance and flavour ingredient, to induce hypersensitivity or to elicit reactions to pre-existing hypersensitivity in the general population was evaluated by analysing patch-test data. Results obtained from fragrance and formulator companies for a total of 10,538 patch tests on benzyl salicylate alone, on a variety of household and personal care consumer products and on fragrance blends containing benzyl salicylate were analysed as part of this survey. No induced or elicited responses directly attributable to benzyl salicylate were observed in the 35 patch tests on benzyl salicylate alone, or in the 10,503 patch tests on consumer products or fragrance blends containing benzyl salicylate. The highest concentration of benzyl salicylate tested in the consumer-product tests was 2 × 10−1%, and benzyl salicylate alone was tested at 10% in ethanol. This study indicates that benzyl salicylate has a very low potential to induce hypersensitivity (‘induced’ reactions) or to elicit reactions presumably attributable to pre-existing sensitization (‘elicited’ reactions) and thus supports the safe use of benzyl salicylate in consumer products and fragrance blends.