COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load.
COVID-19 infection with asymptomatic or mild disease severity in young patients: Clinical course and association between prevalence of pneumonia and viral load.
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DOI：
10.1371/journal.pone.0250358
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Choi WS
中科院分区：
文献类型：
--
作者：
Kim C;Kim W;Jeon JH;Seok H;Kim SB;Choi HK;Yoon YK;Song JY;Park DW;Sohn JW;Choi WS
很少有研究关注年轻无症状或轻度COVID-19感染患者的临床病程或病毒载量。我们试图更好地了解无症状或疾病严重程度较轻的年轻COVID-19患者的临床病程以及病毒载量与肺炎患病率之间的关联。在这项回顾性研究中，分析了106名无症状或疾病严重程度较轻的COVID-19年轻患者的临床特征、临床病程、经放射学证实的肺炎患病率和病毒载量。还研究了存在肺炎的病毒载量临界值。平均年龄为28.0±9.3岁。11例患者（10.4%）在诊断后一周内出现病毒缓解，但1例（0.9%）因肺炎加重而转院。肺炎患者的病毒载量显著高于非肺炎患者，肺炎存在的Ct值的截断值为31.38。肺炎患者的恢复时间明显比未患肺炎的患者慢。腹泻在肺炎患者中明显比非肺炎患者更常见。总之，大多数年轻的无症状和轻度症状的患者表现出稳定的临床过程。有和没有肺炎患者之间的病毒载量和恢复时间有显着差异。
Few studies have focused on clinical courses or viral loads in young asymptomatic or mild patients with COVID-19 infection. We sought to better understand the clinical course and association between viral load and prevalence of pneumonia in young COVID-19 patients with asymptomatic or mild disease severity. In this retrospective study, 106 COVID-19 young patients with asymptomatic or mild disease severity were analyzed for clinical characteristics, clinical course, prevalence of radiologically proven pneumonia and viral load. The cut-off value of viral load for presence of pneumonia was also investigated. The mean age was 28.0±9.3 years. Eleven patients (10.4%) experienced viral remission within one week of diagnosis, but one (0.9%) transferred to the hospital due to aggravation of pneumonia. Patients with pneumonia had significantly higher viral load than those without, and the cut-off value of the Ct value for presence of pneumonia were 31.38. The patients with pneumonia had significantly slower recovery times than those without. Diarrhea was significantly more common in patients with pneumonia than patients without pneumonia. In conclusion, most young asymptomatic and mildly symptomatic patients showed stable clinical course. There were significant differences in viral load and recovery times between patients with and without pneumonia.
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