The effect of organ of Corti loss on ganglion cell survival in humans
The effect of organ of Corti loss on ganglion cell survival in humans
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DOI：
10.1097/01.mao.0000232006.16363.44
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发表时间：
2006-12-01
影响因子：
2.1
通讯作者：
Connell, Sarah S.
中科院分区：
文献类型：
--
作者：
Borne Teufert, Karen;Linthicum, Fred H., Jr.;Connell, Sarah S.
假设：在人类中，螺旋神经节细胞的严重缺失不一定伴随毛细胞或支持细胞的缺失。
背景：尽管有一些相反的研究发表，但在文献中，尤其是关于人工耳蜗植入方面，仍然存在这样的陈述：柯蒂氏器的毛细胞和/或支持细胞的缺失会导致人类螺旋神经节细胞的严重缺失。这种假设显然是基于动物研究或细胞培养，而非人类颞骨研究。
方法：对33只因不同原因导致全聋且耳聋持续时间不同的耳朵的存档颞骨进行形态学分析，并对神经节细胞、毛细胞和支持细胞群进行显微镜和统计学分析。所有耳朵都没有剩余的毛细胞。其中6只耳朵曾植入过人工耳蜗。
结果：神经节细胞计数从2889到34299不等，基于年龄标准数据计算出的剩余神经节细胞的相应百分比与听力损失持续时间（分别为r = -0.13和0.02，p > 0.05）或剩余支持细胞群（r值从0.15到0.27，p > 0.05）均无显著相关性。超过一半的耳朵（51.5%）的神经节细胞计数在年龄标准均值的两个标准差范围内。有外周突（树突）存活的耳朵的平均神经节细胞计数和剩余神经节细胞百分比与无外周突的耳朵相比无显著差异。
结论：在人类中，柯蒂氏器毛细胞和支持细胞的缺失不一定会像在动物中所报道的那样导致螺旋神经节细胞的严重缺失。事实上，我们的结果表明，神经节细胞缺失可能是疾病过程中伴随的一种原发性缺失。
Hypothesis: Severe spiral ganglion cell loss does not necessarily follow loss of hair cells or supporting cells in humans.Background: Despite some publications to the contrary, statements that loss of hair cells and/or supporting cells of the organ of Corti results in a severe loss of spiral ganglion cells in humans still appear in the literature, especially in respect to cochlear implants. This assumption is apparently based on studies in animals or cell culture and not from studies of human temporal bones.Methods: Morphological analysis of archival temporal bones with microscopic and statistical analysis of ganglion cell, hair cell, and supporting cell populations was performed in 33 ears with total hearing losses of varying causes and durations of deafness. None of the ears had remaining hair cells. Six ears had had cochlear implants.Results: Ganglion cell counts ranging from 2,889 to 34,299 and the corresponding percentage of remaining ganglion cells based on age-normative data were not significantly related to the duration of hearing loss (r = -0.13 and 0.02, respectively, p > 0.05) or to remaining supporting cell populations (r's from 0.15 to 0.27, p > 0.05). More than half of ears (51.5%) had ganglion cell counts within two standard deviations of age-normative means. Mean ganglion cell counts and percentage of remaining ganglion cells of ears with surviving peripheral processes (dendrites) did not differ significantly from those of ears with no peripheral processes.Conclusion: The loss of hair and supporting cells in the organ of Corti in humans does not necessarily result in as significant a loss of spiral ganglion cells as has been reported animals. In fact, our results suggest that ganglion cell loss may be a primary concomitant loss due to the disease process.