Evolution of Cardiovascular Disease During the Transition to End-Stage Renal Disease.
Evolution of Cardiovascular Disease During the Transition to End-Stage Renal Disease.
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向终末期肾病过渡期间心血管疾病的演变。
DOI：
10.1016/j.semnephrol.2016.12.002
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发表时间：
2017-03
影响因子：
3.3
通讯作者：
Bansal N
中科院分区：
文献类型：
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作者：
Bansal N
心血管疾病（CVD）仍然是慢性肾病（CKD）和终末期肾病（ESRD）患者发病和死亡的主要原因。透析患者的死亡率仍然很高。这引起了对从CKD到ESRD的关键过渡期期间CVD演变研究的兴趣。了解在这一转变过程中临床和亚临床CVD的自然史和风险因素可能有助于指导适当的CVD治疗时机，以改善肾脏疾病患者的结局。本综述将概述从CKD向ESRD过渡期间亚临床和临床CVD的流行病学，并讨论CVD治疗的临床试验，以降低CKD和ESRD患者的CVD风险。
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD) and end stage renal disease (ESRD). The rate of death in incident dialysis patients remains high. This has led to interest in the study of the evolution of CVD during the critical transition period from CKD to ESRD. Understanding the natural history and risk factors of clinical and subclinical CVD during this transition may help guide the timing of appropriate CVD therapies to improve outcomes in patients with kidney disease. This review will provide an overview of the epidemiology of subclinical and clinical CVD during the transition from CKD to ESRD and discuss clinical trials of CVD therapies to mitigate risk of CVD in CKD and ESRD patients.