Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest
Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest
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DOI：
10.1093/arclin/acq088
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发表时间：
2011-02-01
影响因子：
2.6
通讯作者：
Beglinger, Leigh J.
中科院分区：
文献类型：
--
作者：
O'Rourke, Justin J. F.;Adams, William H.;Beglinger, Leigh J.
对病前能力的评估是神经心理学评估的重要组成部分，特别是在神经退行性疾病中。虽然单词发音测试是估计发病前水平的一种标准方法，但研究表明，这些测试在神经退行性疾病中可能无效。因此，目前的研究试图检查两个估计的病前智力，广泛的成就测试（WRAT）阅读子测试和Barona公式，在93例轻度至中度亨廷顿氏病（HD），以确定其效用，并调查这些措施如何与疾病进展的体征和症状。在89%的参与者中，WRAT的估计低于Barona的估计。WRAT估计与记忆和运动功能恶化有关，而Barona估计的关系较弱。这两种估计都与抑郁或功能能力无关。不规则的文字阅读测试似乎随着HD进展而下降，而基于人口统计学因素的估计方法可能更稳健，但高估了病前功能。
The estimation of premorbid abilities is an essential part of a neuropsychological evaluation, especially in neurodegenerative conditions. Although word pronunciation tests are one standard method for estimating the premorbid level, research suggests that these tests may not be valid in neurodegenerative diseases. Therefore, the current study sought to examine two estimates of premorbid intellect, the Wide Range Achievement Test (WRAT) Reading subtest and the Barona formula, in 93 patients with mild to moderate Huntington's disease (HD) to determine their utility and to investigate how these measures relate to signs and symptoms of disease progression. In 89% of participants, WRAT estimates were below the Barona estimates. WRAT estimates were related to worsening memory and motor functioning, whereas the Barona estimates had weaker relationships. Neither estimate was related to depression or functional capacity. Irregular word reading tests appear to decline with HD progression, whereas estimation methods based on demographic factors may be more robust but overestimate premorbid functioning.