TTF-1 expression in pulmonary adenocarcinomas
TTF-1 expression in pulmonary adenocarcinomas
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DOI：
10.1097/00000478-200206000-00010
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发表时间：
2002-06-01
影响因子：
5.6
通讯作者：
Takahashi, T
中科院分区：
文献类型：
--
作者：
Yatabe, Y;Mitsudomi, T;Takahashi, T
组织特异性基因表达在很大程度上是由转录因子介导的，因此主控调控基因是细胞谱系的潜在标志。采用正常胎至成人肺组织和连续肺腺癌组织，检测了在正常肺功能和形态发生中起重要作用的甲状腺转录因子-1的表达。TTF-1在整个生命阶段持续表达，并在由外周呼吸道细胞和小细支气管所组成的终末呼吸单位中均匀表达。此外，在与表面活性物质载脂蛋白高度相关的腺癌中，有72%的细胞维持表达(p
Tissue-specific gene expression is mediated largely by transcription factors, and a master regulatory gene is thus a potential marker of cellular lineage. Using normal fetal through adult pulmonary tissues and 64 consecutive lung adenocarcinomas, we examined the expression of thyroid transcription factor (TTF-1), Which plays a crucial role in normal lung function and morphogenesis. TTF-1 was expressed consistently throughout the life stages and uniformly in the terminal respiratory unit, which is comprised of peripheral airway cells and small-sized bronchioles. Furthermore, the expression was maintained in 72% of adenocarcinomas that exhibited high correlation with surfactant apoprotein (p