Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine.
Prior Helicobacter pylori infection ameliorates Salmonella typhimurium-induced colitis: mucosal crosstalk between stomach and distal intestine.
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DOI：
10.1002/ibd.21489
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发表时间：
2011-06
影响因子：
4.9
通讯作者：
Kao, John Y.
中科院分区：
文献类型：
--
作者：
Higgins, Peter D. R.;Johnson, Laura A.;Luther, Jay;Zhang, Min;Sauder, Kay L.;Blanco, Luz P.;Kao, John Y.
幽门螺杆菌感染与慢性自身免疫性疾病（包括炎症性肠病）的风险降低有关。幽门螺杆菌调节胃免疫反应，减少对其自身的局部炎症反应。在小鼠中，慢性鼠伤寒沙门氏菌感染会诱发类似于克罗恩病的结肠炎，其特征是炎症进展为纤维化。本研究的目的是确定先前的幽门螺杆菌感染是否在远处发挥作用来调节鼠伤寒沙门氏菌诱导的结肠炎的免疫反应。小鼠感染了适应小鼠的幽门螺杆菌菌株（SS1），然后感染了鼠伤寒沙门氏菌。幽门螺杆菌对结肠炎的影响通过大体病理学、组织病理学、细胞因子反应和盲肠纤维化的发展来确定。测量胃炎和全身免疫反应对感染的反应。幽门螺杆菌抑制小鼠盲肠中针对鼠伤寒沙门氏菌感染的 Th17 反应，但不会改变 Th2 或 Treg 反应或纤维化的发展。幽门螺杆菌感染会在肠系膜淋巴结中诱导 IL-10，这表明存在胃外免疫调节机制。幽门螺杆菌/S。鼠伤寒复合感染可减轻盲肠和胃的炎症。这项研究证明了幽门螺杆菌与人类 IBD 之间负相关的潜在机制。幽门螺杆菌通过胃外免疫调节作用抑制下胃肠道 Th17 对细菌诱导的结肠炎的反应，这说明了上胃肠道和下胃肠道之间的免疫串扰。
Helicobacter pylori infection is associated with a lower risk of chronic autoimmune diseases including IBD. H. pylori modulates the gastric immune response, decreasing the local inflammatory response to itself. In mice, chronic Salmonella typhimurium infection induces colitis similar to Crohn’s disease characterized by inflammation which progresses towards fibrosis. The aim of this study was to determine whether prior H. pylori infection acts at a distance to modulate the immune response of S. typhimurium-induced colitis. Mice were infected with the mouse-adapted strain of H. pylori (SS1), followed by infection with S. typhimurium. The effect of H. pylori on colitis was determined by gross pathology, histopathology, cytokine response, and development of fibrosis in the cecum. Gastritis and systemic immune response was measured in response to infection. H. pylori suppresses the Th17 response to S. typhimurium infection in the mouse cecum, but does not alter the Th2 or Treg response or the development of fibrosis. H. pylori infection induces IL-10 in the mesenteric lymph nodes, suggesting an extra-gastric mechanism for immunomodulation. H. pylori/S. typhimurium co-infection decreases inflammation in both the cecum and the stomach. This study demonstrates a potential mechanism for the negative association between H. pylori and IBD in humans. H. pylori represses the lower gastrointestinal tract Th17 response to bacterially induced colitis via extra-gastric immunomodulatory effects, illustrating immunological crosstalk between the upper and lower gastrointestinal tract.
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影响因子：
14.8
作者：
Wirtz, Stefan;Neufert, Clemens;Neurath, Markus F.
通讯作者：
Neurath, Markus F.
影响因子：
158.5
作者：
Oldach, DW;Borza, EN;Benitez, RM
通讯作者：
Benitez, RM
影响因子：
8.4
作者：
Papagrigorakis, Manolis J.;Yapijakis, Christos;Baziotopoulou-Valavani, Effie
通讯作者：
Baziotopoulou-Valavani, Effie
影响因子：
29.4
作者：
Rad, Roland;Brenner, Lena;Prinz, Christian
通讯作者：
Prinz, Christian
DOI：
10.1152/ajpgi.1999.276.6.g1317
发表时间：
1999-06-01
影响因子：
4.5
作者：
De Winter, H;Cheroutre, H;Kronenberg, M
通讯作者：
Kronenberg, M