A model of parity-dependent immunity to placental malaria
A model of parity-dependent immunity to placental malaria
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DOI：
10.1038/ncomms2605
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发表时间：
2013-03-01
影响因子：
16.6
通讯作者：
Ghani, Azra C.
中科院分区：
文献类型：
--
作者：
Walker, Patrick G. T.;Griffin, Jamie T.;Ghani, Azra C.
妊娠期胎盘感染恶性疟原虫对母亲和孩子都有害。对胎盘感染的保护是胎次依赖性的，即在连续怀孕期间获得。然而，胎盘的感染状况只能在分娩时评估。在这里，为了更好地理解这种胎次依赖的机制，我们拟合了一个模型，将普通人群中的疟疾动态与观察到的胎盘组织学联系起来。我们的研究结果表明，与阻止胎盘隔离的免疫相比，导致较短时间感染的免疫是胎次特异性模式的更大决定因素。我们的研究结果还表明，母体血液首次流入胎盘的时间是一个高风险时期。因此，在怀孕前或怀孕早期实施预防性战略，如育龄妇女使用经杀虫剂处理过的蚊帐或今后接种任何疫苗，可大大减少遭受胎盘感染的妇女人数。
Plasmodium falciparum placental infection during pregnancy is harmful for both mother and child. Protection from placental infection is parity-dependent, that is, acquired over consecutive pregnancies. However, the infection status of the placenta can only be assessed at delivery. Here, to better understand the mechanism underlying this parity-dependence, we fitted a model linking malaria dynamics within the general population to observed placental histology. Our results suggest that immunity resulting in less prolonged infection is a greater determinant of the parity-specific patterns than immunity that prevents placental sequestration. Our results also suggest the time when maternal blood first flows into the placenta is a high-risk period. Therefore, preventative strategies implementable before or early in pregnancy, such as insecticide-treated net usage in women of child-bearing age or any future vaccine, could substantially reduce the number of women who experience placental infection.