Lower cognitive performance among long-term type 1 diabetes survivors A case-control study
Lower cognitive performance among long-term type 1 diabetes survivors A case-control study
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DOI：
10.1016/j.jdiacomp.2017.04.023
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发表时间：
2017-08-01
影响因子：
3
通讯作者：
Eliasson, Mats
中科院分区：
文献类型：
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作者：
Awad, Anna;Lundqvist, Robert;Eliasson, Mats
目的：1 型糖尿病 (T1D) 患者出现认知功能障碍的风险增加。据信认知能力下降取决于大血管和微血管并发症以及较长的病程。有些患者没有出现这些并发症，但仍然报告认知症状。我们检查了长期无并发症的 T1D 是否与较低的认知能力相关。方法：将一组无微血管或大血管并发症的长期 T1D（> 30 岁）患者（n = 43）与非糖尿病对照组（n = 86）进行六项认知测试进行比较，这些测试探讨了情景记忆、语义记忆、情景短期记忆、视觉注意力和精神运动速度。每个患者都与年龄、性别和教育程度方面的两名对照组相匹配。使用线性混合效应模型来分析数据。结果：平均年龄为 57 岁，平均病程为 41 年。糖尿病患者的舒张压较低，但体重指数、腰围、收缩压和吸烟情况在各组之间没有差异。患者的情景短期记忆结果低于非糖尿病对照者 (p < 0.001)，并且在反映视觉注意力和精神运动速度的测试中的值也较低 (p = 0.019)。结论：无论其他糖尿病相关并发症如何，长期 T1D 与较低的认知能力相关。 (C) 2017 Elsevier Inc. 保留所有权利。
Objective: Patients with type 1 diabetes (T1D) have an increased risk of cognitive dysfunction. The cognitive decrement is believed to depend on macro- and microvascular complications and long disease duration. Some patients do not develop these complications, but still report cognitive symptoms. We examined if long-standing T1D without complications is associated with lower cognitive performance.Methods: A group of patients (n = 43) with long-standing T1D (>30 years) without micro- or macro vascular complications was compared with a non-diabetic control group (n = 86) on six cognitive tests which probed episodic memory, semantic memory, episodic short-term memory, visual attention and psychomotor speed. Each patient was matched with two controls regarding age, gender and education. A linear mixed effect model was used to analyze the data.Results: The mean age was 57 years and mean duration was 41 years. Patients with diabetes had lower diastolic blood pressure but BMI, waist circumference, systolic blood pressure and smoking did not differ between groups. Patients had lower results than non-diabetic controls in episodic short-term memory (p < 0.001) and also lower values on a test that mirrors visual attention and psychomotor speed (p = 0.019).Conclusions: Long-standing T1D was associated with lower cognitive performance, regardless of other diabetes-related complications. (C) 2017 Elsevier Inc. All rights reserved.