miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis
miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis
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DOI：
10.1101/gad.1975411
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发表时间：
2011-01-15
影响因子：
10.5
通讯作者：
Deshmukh, Mohanish
中科院分区：
文献类型：
--
作者：
Kole, Adam J.;Swahari, Vijay;Deshmukh, Mohanish
细胞凋亡的执行对于神经系统的正常发育至关重要。然而，同样重要的是，神经元在发育后严格抑制凋亡，以确保它们在生物体的整个生命周期中存活。在这里，我们表明，micro-RNA，miR-29 b，显着诱导神经元的成熟和功能作为一种新的抑制剂的神经元凋亡。miR-29 b的促生存功能是通过靶向促凋亡BH 3-only家族中的基因介导的。我们的研究结果确定了一种独特的策略，通过成熟的神经元，使用单一的microRNA来抑制多个，冗余的BH 3-only蛋白，这些蛋白是细胞凋亡的关键启动子。
The execution of apoptosis is critical for proper development of the nervous system. However, it is equally important that neurons strictly inhibit apoptosis after development to ensure their survival throughout the lifetime of the organism. Here we show that a micro-RNA, miR-29b, is markedly induced with neuronal maturation and functions as a novel inhibitor of neuronal apoptosis. The prosurvival function of miR-29b is mediated by targeting genes in the proapoptotic BH3-only family. Our results identify a unique strategy evolved by maturing neurons that uses a single microRNA to inhibit the multiple, redundant BH3-only proteins that are key initiators of apoptosis.